Abstract
We disclose herein a catalyst-free, room-temperature protocol for the highly regio- and stereoselective alkenyl C(sp2)-H chlorination of diverse enamides with commercially available, inexpensive N-chlorosuccinimide (NCS) as the electrophilic chlorinating reagent under exceedingly mild conditions. This operationally simple approach features a remarkably broad substrate scope and accommodates excellent functional group tolerance, affording a diverse range of synthetically valuable geometrically defined β-chlorinated enamides in high yields with an exclusive E configuration.
Original language | English |
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Journal | Organic Letters |
DOIs | |
Publication status | Accepted/In press - 2025 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2025 American Chemical Society.
ASJC Scopus Subject Areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry