Catalytic enantioselective conjugate addition of Grignard reagents to cyclic enones using C 1-1,1′-bisisoquinoline-based chiral ligands

Gao Qi; Zaher M.A. Judeh

doi:10.1080/00397911.2010.541969

Catalytic enantioselective conjugate addition of Grignard reagents to cyclic enones using C ₁-1,1′-bisisoquinoline-based chiral ligands

Gao Qi, Zaher M.A. Judeh^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

New highly constrained chiral C ₁-1,1′-bisisoquinoline ligands were examined in the enantioselective conjugate addition of Grignard reagents to cyclohexenone and cyclopentenone. The desired 1,4-adducts were obtained in excellent yield and moderate enantiomeric excess (up to 35%).

Original language	English
Pages (from-to)	1585-1592
Number of pages	8
Journal	Synthetic Communications
Volume	42
Issue number	11
DOIs	https://doi.org/10.1080/00397911.2010.541969
Publication status	Published - 2012
Externally published	Yes

ASJC Scopus Subject Areas

Organic Chemistry

Keywords

Asymmetric catalysis
C -1,1′-bisisoquinoline
Cyclic enones
Enantioselective conjugate addition

Access to Document

10.1080/00397911.2010.541969

Cite this

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abstract = "New highly constrained chiral C 1-1,1′-bisisoquinoline ligands were examined in the enantioselective conjugate addition of Grignard reagents to cyclohexenone and cyclopentenone. The desired 1,4-adducts were obtained in excellent yield and moderate enantiomeric excess (up to 35%).",

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AU - Qi, Gao

AU - Judeh, Zaher M.A.

PY - 2012

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N2 - New highly constrained chiral C 1-1,1′-bisisoquinoline ligands were examined in the enantioselective conjugate addition of Grignard reagents to cyclohexenone and cyclopentenone. The desired 1,4-adducts were obtained in excellent yield and moderate enantiomeric excess (up to 35%).

AB - New highly constrained chiral C 1-1,1′-bisisoquinoline ligands were examined in the enantioselective conjugate addition of Grignard reagents to cyclohexenone and cyclopentenone. The desired 1,4-adducts were obtained in excellent yield and moderate enantiomeric excess (up to 35%).

KW - Asymmetric catalysis

KW - C -1,1′-bisisoquinoline

KW - Cyclic enones

KW - Enantioselective conjugate addition

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