CG-NAP/Kinase Interactions Fine-Tune T Cell Functions

Navin Kumar Verma; Madhavi Latha Somaraju Chalasani; John D. Scott; Dermot Kelleher

doi:10.3389/fimmu.2019.02642

CG-NAP/Kinase Interactions Fine-Tune T Cell Functions

Navin Kumar Verma^*, Madhavi Latha Somaraju Chalasani, John D. Scott, Dermot Kelleher

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

CG-NAP, also known as AKAP450, is an anchoring/adaptor protein that streamlines signal transduction in various cell types by localizing signaling proteins and enzymes with their substrates. Great efforts are being devoted to elucidating functional roles of this protein and associated macromolecular signaling complex. Increasing understanding of pathways involved in regulating T lymphocytes suggests that CG-NAP can facilitate dynamic interactions between kinases and their substrates and thus fine-tune T cell motility and effector functions. As a result, new binding partners of CG-NAP are continually being uncovered. Here, we review recent advances in CG-NAP research, focusing on its interactions with kinases in T cells with an emphasis on the possible role of this anchoring protein as a target for therapeutic intervention in immune-mediated diseases.

Original language	English
Article number	2642
Journal	Frontiers in Immunology
Volume	10
DOIs	https://doi.org/10.3389/fimmu.2019.02642
Publication status	Published - Nov 12 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© Copyright © 2019 Verma, Chalasani, Scott and Kelleher.

ASJC Scopus Subject Areas

Immunology and Allergy
Immunology

Keywords

adaptor protein
AKAP450
CG-NAP
immune synapse
kinases
T cell motility

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10.3389/fimmu.2019.02642

Cite this

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abstract = "CG-NAP, also known as AKAP450, is an anchoring/adaptor protein that streamlines signal transduction in various cell types by localizing signaling proteins and enzymes with their substrates. Great efforts are being devoted to elucidating functional roles of this protein and associated macromolecular signaling complex. Increasing understanding of pathways involved in regulating T lymphocytes suggests that CG-NAP can facilitate dynamic interactions between kinases and their substrates and thus fine-tune T cell motility and effector functions. As a result, new binding partners of CG-NAP are continually being uncovered. Here, we review recent advances in CG-NAP research, focusing on its interactions with kinases in T cells with an emphasis on the possible role of this anchoring protein as a target for therapeutic intervention in immune-mediated diseases.",

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AU - Verma, Navin Kumar

AU - Chalasani, Madhavi Latha Somaraju

AU - Scott, John D.

AU - Kelleher, Dermot

PY - 2019/11/12

Y1 - 2019/11/12

N2 - CG-NAP, also known as AKAP450, is an anchoring/adaptor protein that streamlines signal transduction in various cell types by localizing signaling proteins and enzymes with their substrates. Great efforts are being devoted to elucidating functional roles of this protein and associated macromolecular signaling complex. Increasing understanding of pathways involved in regulating T lymphocytes suggests that CG-NAP can facilitate dynamic interactions between kinases and their substrates and thus fine-tune T cell motility and effector functions. As a result, new binding partners of CG-NAP are continually being uncovered. Here, we review recent advances in CG-NAP research, focusing on its interactions with kinases in T cells with an emphasis on the possible role of this anchoring protein as a target for therapeutic intervention in immune-mediated diseases.

AB - CG-NAP, also known as AKAP450, is an anchoring/adaptor protein that streamlines signal transduction in various cell types by localizing signaling proteins and enzymes with their substrates. Great efforts are being devoted to elucidating functional roles of this protein and associated macromolecular signaling complex. Increasing understanding of pathways involved in regulating T lymphocytes suggests that CG-NAP can facilitate dynamic interactions between kinases and their substrates and thus fine-tune T cell motility and effector functions. As a result, new binding partners of CG-NAP are continually being uncovered. Here, we review recent advances in CG-NAP research, focusing on its interactions with kinases in T cells with an emphasis on the possible role of this anchoring protein as a target for therapeutic intervention in immune-mediated diseases.

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KW - kinases

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CG-NAP/Kinase Interactions Fine-Tune T Cell Functions

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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