Characterization of a carbonyl-conjugated polyene precursor in 10-membered enediyne biosynthesis

Rong Kong; Lan Pei Goh; Chong Wai Liew; Qin Shi Ho; Elavazhagan Murugan; Bin Li; Kai Tang; Zhao Xun Liang

doi:10.1021/ja8019643

Characterization of a carbonyl-conjugated polyene precursor in 10-membered enediyne biosynthesis

Rong Kong, Lan Pei Goh, Chong Wai Liew, Qin Shi Ho, Elavazhagan Murugan, Bin Li, Kai Tang, Zhao Xun Liang^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

We have characterized a linear carbonyl-conjugated polyene generated by the iterative polyketide synthase (CalE8) involved in the biosynthesis of the 10-membered enediyne core of calicheamicin. The results provide insight into the mysterious biosynthetic mechanism of the unique enediyne. The carbonyl-conjugated polyene differs from the precursor for 9-membered enediyne, suggesting that the divergence of enediyne biosynthesis starts at the PKS stage.

Original language	English
Pages (from-to)	8142-8143
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	130
Issue number	26
DOIs	https://doi.org/10.1021/ja8019643
Publication status	Published - Jul 2 2008
Externally published	Yes

ASJC Scopus Subject Areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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abstract = "We have characterized a linear carbonyl-conjugated polyene generated by the iterative polyketide synthase (CalE8) involved in the biosynthesis of the 10-membered enediyne core of calicheamicin. The results provide insight into the mysterious biosynthetic mechanism of the unique enediyne. The carbonyl-conjugated polyene differs from the precursor for 9-membered enediyne, suggesting that the divergence of enediyne biosynthesis starts at the PKS stage.",

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AU - Kong, Rong

AU - Goh, Lan Pei

AU - Liew, Chong Wai

AU - Ho, Qin Shi

AU - Murugan, Elavazhagan

AU - Li, Bin

AU - Tang, Kai

AU - Liang, Zhao Xun

PY - 2008/7/2

Y1 - 2008/7/2

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AB - We have characterized a linear carbonyl-conjugated polyene generated by the iterative polyketide synthase (CalE8) involved in the biosynthesis of the 10-membered enediyne core of calicheamicin. The results provide insight into the mysterious biosynthetic mechanism of the unique enediyne. The carbonyl-conjugated polyene differs from the precursor for 9-membered enediyne, suggesting that the divergence of enediyne biosynthesis starts at the PKS stage.

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JF - Journal of the American Chemical Society

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ER -

Characterization of a carbonyl-conjugated polyene precursor in 10-membered enediyne biosynthesis

Abstract

ASJC Scopus Subject Areas

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