Chemiluminescence: From mechanism to applications in biological imaging and therapy

Zhijia Wang; Jiaguo Huang; Jingsheng Huang; Bingran Yu; Kanyi Pu; Fu Jian Xu

doi:10.1002/agt2.140

Chemiluminescence: From mechanism to applications in biological imaging and therapy

Zhijia Wang, Jiaguo Huang, Jingsheng Huang, Bingran Yu, Kanyi Pu^*, Fu Jian Xu^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

66 Citations (Scopus)

Abstract

Chemiluminescence (CL) is an emission phenomenon induced by chemical reaction. Different from the photoluminescence, CL is free from external excitation source, which is expected to show great advantages such as higher signal-to-background ratio (SBR) in bioimaging, and deeper tissue penetration in photodynamic therapy (PDT). This review introduces the theoretical aspects of CL mechanism, such as classification, energy consideration and chemiexcited/photoexcited states. Application of CL in bioimaging is highlighted. In particular, the approaches to modulate the brightness and the wavelength of CL are summarized, which are two fundamental parameters in bioimaging. Finally, the application of CL in PDT is introduced. The potential challenges and perspectives of CL in bioimaging and therapy are also discussed.

Original language	English
Article number	e140
Journal	Aggregate
Volume	2
Issue number	6
DOIs	https://doi.org/10.1002/agt2.140
Publication status	Published - Dec 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 The Authors. Aggregate published by John Wiley & Sons Australia, Ltd on behalf of South China University of Technology and AIE Institute.

ASJC Scopus Subject Areas

Chemistry (miscellaneous)
Materials Science (miscellaneous)
Materials Chemistry
Molecular Biology

Keywords

chemiluminescence
imaging
molecular probes
photodynamic therapy

Access to Document

10.1002/agt2.140

Cite this

@article{a1278331586e46758d9188f7e8b3efd0,

title = "Chemiluminescence: From mechanism to applications in biological imaging and therapy",

abstract = "Chemiluminescence (CL) is an emission phenomenon induced by chemical reaction. Different from the photoluminescence, CL is free from external excitation source, which is expected to show great advantages such as higher signal-to-background ratio (SBR) in bioimaging, and deeper tissue penetration in photodynamic therapy (PDT). This review introduces the theoretical aspects of CL mechanism, such as classification, energy consideration and chemiexcited/photoexcited states. Application of CL in bioimaging is highlighted. In particular, the approaches to modulate the brightness and the wavelength of CL are summarized, which are two fundamental parameters in bioimaging. Finally, the application of CL in PDT is introduced. The potential challenges and perspectives of CL in bioimaging and therapy are also discussed.",

keywords = "chemiluminescence, imaging, molecular probes, photodynamic therapy",

author = "Zhijia Wang and Jiaguo Huang and Jingsheng Huang and Bingran Yu and Kanyi Pu and Xu, {Fu Jian}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors. Aggregate published by John Wiley & Sons Australia, Ltd on behalf of South China University of Technology and AIE Institute.",

year = "2021",

month = dec,

doi = "10.1002/agt2.140",

language = "English",

volume = "2",

journal = "Aggregate",

issn = "2766-8541",

number = "6",

}

TY - JOUR

T1 - Chemiluminescence

T2 - From mechanism to applications in biological imaging and therapy

AU - Wang, Zhijia

AU - Huang, Jiaguo

AU - Huang, Jingsheng

AU - Yu, Bingran

AU - Pu, Kanyi

AU - Xu, Fu Jian

PY - 2021/12

Y1 - 2021/12

N2 - Chemiluminescence (CL) is an emission phenomenon induced by chemical reaction. Different from the photoluminescence, CL is free from external excitation source, which is expected to show great advantages such as higher signal-to-background ratio (SBR) in bioimaging, and deeper tissue penetration in photodynamic therapy (PDT). This review introduces the theoretical aspects of CL mechanism, such as classification, energy consideration and chemiexcited/photoexcited states. Application of CL in bioimaging is highlighted. In particular, the approaches to modulate the brightness and the wavelength of CL are summarized, which are two fundamental parameters in bioimaging. Finally, the application of CL in PDT is introduced. The potential challenges and perspectives of CL in bioimaging and therapy are also discussed.

AB - Chemiluminescence (CL) is an emission phenomenon induced by chemical reaction. Different from the photoluminescence, CL is free from external excitation source, which is expected to show great advantages such as higher signal-to-background ratio (SBR) in bioimaging, and deeper tissue penetration in photodynamic therapy (PDT). This review introduces the theoretical aspects of CL mechanism, such as classification, energy consideration and chemiexcited/photoexcited states. Application of CL in bioimaging is highlighted. In particular, the approaches to modulate the brightness and the wavelength of CL are summarized, which are two fundamental parameters in bioimaging. Finally, the application of CL in PDT is introduced. The potential challenges and perspectives of CL in bioimaging and therapy are also discussed.

KW - chemiluminescence

KW - imaging

KW - molecular probes

KW - photodynamic therapy

UR - http://www.scopus.com/inward/record.url?scp=85164815195&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85164815195&partnerID=8YFLogxK

U2 - 10.1002/agt2.140

DO - 10.1002/agt2.140

M3 - Review article

AN - SCOPUS:85164815195

SN - 2766-8541

VL - 2

JO - Aggregate

JF - Aggregate

IS - 6

M1 - e140

ER -

Chemiluminescence: From mechanism to applications in biological imaging and therapy

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

Other files and links

Fingerprint

Cite this