TY - JOUR
T1 - Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome 1
AU - Lee, Simon Ming Yuen
AU - Tsui, Stephen Kwok Wing
AU - Chan, Kwok Keung
AU - Kotaka, Masayo
AU - Li, Hoi Yeung
AU - Chim, Stephen Siu Chung
AU - Waye, Mary Miu Yee
AU - Fung, Kwok Pui
AU - Lee, Cheuk Yu
PY - 1998
Y1 - 1998
N2 - Four-and-a-half LIM domain proteins (FHL) possess four tandem repeats of LIM domain and an extra zinc finger. FHL family LIM proteins are unique when compared with other LIM-only proteins because they possess an odd number of zinc fingers. In this study, the tissue distribution and chromosomal mapping of skeletal muscle LIM protein FHL3 were reported. When the FHL3 cDNA probe was used to hybridize with poly-(A) RNA of various human tissues, a very strong signal was detected in skeletal muscle, and virtually no signal could be detected in heart, brain, placenta, lung, liver, kidney and pancreas. Using radiation hybrid technique, FHL3 gene was mapped to the distal end of the short arm of chromosome 1 (123.26 cR from the top of the Chr1 linkage group) and this region (near 1p34) is related to several human malignancies.
AB - Four-and-a-half LIM domain proteins (FHL) possess four tandem repeats of LIM domain and an extra zinc finger. FHL family LIM proteins are unique when compared with other LIM-only proteins because they possess an odd number of zinc fingers. In this study, the tissue distribution and chromosomal mapping of skeletal muscle LIM protein FHL3 were reported. When the FHL3 cDNA probe was used to hybridize with poly-(A) RNA of various human tissues, a very strong signal was detected in skeletal muscle, and virtually no signal could be detected in heart, brain, placenta, lung, liver, kidney and pancreas. Using radiation hybrid technique, FHL3 gene was mapped to the distal end of the short arm of chromosome 1 (123.26 cR from the top of the Chr1 linkage group) and this region (near 1p34) is related to several human malignancies.
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U2 - 10.1023/B:SCAM.0000007122.03392.4b
DO - 10.1023/B:SCAM.0000007122.03392.4b
M3 - Article
C2 - 10226657
AN - SCOPUS:0032417228
SN - 0740-7750
VL - 24
SP - 197
EP - 202
JO - Somatic Cell and Molecular Genetics
JF - Somatic Cell and Molecular Genetics
IS - 3
ER -