TY - JOUR
T1 - Combinatorial treatment of photothermal therapy using gold nanoshells with conventional photodynamic therapy to improve treatment efficacy
T2 - An in vitro study
AU - Kah, James Chen Yong
AU - Wan, Rachel Cheng Yi
AU - Wong, Ker Yi
AU - Mhaisalkar, Subodh
AU - Sheppard, Colin James Richard
AU - Olivo, Malini
PY - 2008/10
Y1 - 2008/10
N2 - Background and Objective: Both photodynamic (PDT) and photothermal (PTT) therapy have proven to be effective treatment strategies for cancer, but the approach of combining them into a single treatment modality may offer better treatment efficacy. We compare the treatment efficacy of such combined treatment with the individual treatment. Study Design/Materials and Methods: We perform the individual PDT, PTT and combined treatment under selected in vitro condition with our low light dose of 1.44 J/cm2 and compare their cell viability using crystal fast violet assay. Results: Compared to PDT and PTT alone which can reduce cell viability to 30.9% and 44.0% respectively, the combined treatment under a single irradiation can further reduce the cell viability to 17.5%. Conclusion: A combined PDT and PTT treatment appears to be a more effective treatment strategy compared to conventional PDT or emerging PTT treatment.
AB - Background and Objective: Both photodynamic (PDT) and photothermal (PTT) therapy have proven to be effective treatment strategies for cancer, but the approach of combining them into a single treatment modality may offer better treatment efficacy. We compare the treatment efficacy of such combined treatment with the individual treatment. Study Design/Materials and Methods: We perform the individual PDT, PTT and combined treatment under selected in vitro condition with our low light dose of 1.44 J/cm2 and compare their cell viability using crystal fast violet assay. Results: Compared to PDT and PTT alone which can reduce cell viability to 30.9% and 44.0% respectively, the combined treatment under a single irradiation can further reduce the cell viability to 17.5%. Conclusion: A combined PDT and PTT treatment appears to be a more effective treatment strategy compared to conventional PDT or emerging PTT treatment.
KW - Epidermal growth factor receptor (EGFR)
KW - Gold nanoshells
KW - Hypericin
KW - Photodynamic therapy (PDT)
KW - Photothermal therapy (PTT)
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U2 - 10.1002/lsm.20674
DO - 10.1002/lsm.20674
M3 - Article
C2 - 18798290
AN - SCOPUS:53249144150
SN - 0196-8092
VL - 40
SP - 584
EP - 589
JO - Lasers in Surgery and Medicine
JF - Lasers in Surgery and Medicine
IS - 8
ER -
