Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss

Martin Kallab; Nikolaus Hommer; Andreas Schlatter; Jacqueline Chua; Bingyao Tan; Doreen Schmidl; Cornelia Hirn; Oliver Findl; Leopold Schmetterer; Gerhard Garhöfer; Damon Wong

doi:10.1111/nyas.14732

Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss

Martin Kallab, Nikolaus Hommer, Andreas Schlatter, Jacqueline Chua, Bingyao Tan, Doreen Schmidl, Cornelia Hirn, Oliver Findl, Leopold Schmetterer, Gerhard Garhöfer, Damon Wong^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

We compare the focal structure–function correlation of structural measurements of peripapillary retinal nerve fiber layer thickness (RNFL-T) using optical coherence tomography (OCT), capillary density (CD) measurements using OCT-angiography (OCT-A), or a combination of both, with visual field deviation (VFD) in early to advanced glaucoma. Primary open angle glaucoma patients (n = 46, mean ± SD age: 67 ± 10 years; VF mean deviation: −10.41 ± 6.76 dB) were included in this cross-sectional study. We performed 30–2 standard automated perimetry OCT (3.5-mm diameter ring scan) and 15°×15° OCT-A (superficial vascular complex slab). Based on a nerve fiber trajectory model, each VF test spot was assigned to an OCT-A wedge and an OCT ring-sector. Two univariate linear models (M_v and M_t) using either CD-based vascular (M_v) or RNFL-T–based thickness information (M_t) and one multivariate model using both (M_v:t) were compared in their associations with measured focal VFD, which were higher for the multivariate model M_v:t (mean ± SD correlation coefficient: 0.710 ± 0.086) than for either nested model (0.627 ± 0.078 for M_v and 0.578 ± 0.095 for M_t). Using a focal visual field approach, the combination of RNFL-T and CD showed better structure–function correlations than thickness or vascular information only.

Original language	English
Pages (from-to)	133-141
Number of pages	9
Journal	Annals of the New York Academy of Sciences
Volume	1511
Issue number	1
DOIs	https://doi.org/10.1111/nyas.14732
Publication status	Published - May 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals LLC on behalf of New York Academy of Sciences.

ASJC Scopus Subject Areas

General Neuroscience
General Biochemistry,Genetics and Molecular Biology
History and Philosophy of Science

Keywords

glaucoma
optical coherence tomography angiography
retinal nerve fiber layer
structure–function correlation
visual field

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10.1111/nyas.14732

Cite this

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title = "Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss",

abstract = "We compare the focal structure–function correlation of structural measurements of peripapillary retinal nerve fiber layer thickness (RNFL-T) using optical coherence tomography (OCT), capillary density (CD) measurements using OCT-angiography (OCT-A), or a combination of both, with visual field deviation (VFD) in early to advanced glaucoma. Primary open angle glaucoma patients (n = 46, mean ± SD age: 67 ± 10 years; VF mean deviation: −10.41 ± 6.76 dB) were included in this cross-sectional study. We performed 30–2 standard automated perimetry OCT (3.5-mm diameter ring scan) and 15°×15° OCT-A (superficial vascular complex slab). Based on a nerve fiber trajectory model, each VF test spot was assigned to an OCT-A wedge and an OCT ring-sector. Two univariate linear models (Mv and Mt) using either CD-based vascular (Mv) or RNFL-T–based thickness information (Mt) and one multivariate model using both (Mv:t) were compared in their associations with measured focal VFD, which were higher for the multivariate model Mv:t (mean ± SD correlation coefficient: 0.710 ± 0.086) than for either nested model (0.627 ± 0.078 for Mv and 0.578 ± 0.095 for Mt). Using a focal visual field approach, the combination of RNFL-T and CD showed better structure–function correlations than thickness or vascular information only.",

keywords = "glaucoma, optical coherence tomography angiography, retinal nerve fiber layer, structure–function correlation, visual field",

author = "Martin Kallab and Nikolaus Hommer and Andreas Schlatter and Jacqueline Chua and Bingyao Tan and Doreen Schmidl and Cornelia Hirn and Oliver Findl and Leopold Schmetterer and Gerhard Garh{\"o}fer and Damon Wong",

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year = "2022",

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doi = "10.1111/nyas.14732",

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AU - Kallab, Martin

AU - Hommer, Nikolaus

AU - Schlatter, Andreas

AU - Chua, Jacqueline

AU - Tan, Bingyao

AU - Schmidl, Doreen

AU - Hirn, Cornelia

AU - Findl, Oliver

AU - Schmetterer, Leopold

AU - Garhöfer, Gerhard

AU - Wong, Damon

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N2 - We compare the focal structure–function correlation of structural measurements of peripapillary retinal nerve fiber layer thickness (RNFL-T) using optical coherence tomography (OCT), capillary density (CD) measurements using OCT-angiography (OCT-A), or a combination of both, with visual field deviation (VFD) in early to advanced glaucoma. Primary open angle glaucoma patients (n = 46, mean ± SD age: 67 ± 10 years; VF mean deviation: −10.41 ± 6.76 dB) were included in this cross-sectional study. We performed 30–2 standard automated perimetry OCT (3.5-mm diameter ring scan) and 15°×15° OCT-A (superficial vascular complex slab). Based on a nerve fiber trajectory model, each VF test spot was assigned to an OCT-A wedge and an OCT ring-sector. Two univariate linear models (Mv and Mt) using either CD-based vascular (Mv) or RNFL-T–based thickness information (Mt) and one multivariate model using both (Mv:t) were compared in their associations with measured focal VFD, which were higher for the multivariate model Mv:t (mean ± SD correlation coefficient: 0.710 ± 0.086) than for either nested model (0.627 ± 0.078 for Mv and 0.578 ± 0.095 for Mt). Using a focal visual field approach, the combination of RNFL-T and CD showed better structure–function correlations than thickness or vascular information only.

AB - We compare the focal structure–function correlation of structural measurements of peripapillary retinal nerve fiber layer thickness (RNFL-T) using optical coherence tomography (OCT), capillary density (CD) measurements using OCT-angiography (OCT-A), or a combination of both, with visual field deviation (VFD) in early to advanced glaucoma. Primary open angle glaucoma patients (n = 46, mean ± SD age: 67 ± 10 years; VF mean deviation: −10.41 ± 6.76 dB) were included in this cross-sectional study. We performed 30–2 standard automated perimetry OCT (3.5-mm diameter ring scan) and 15°×15° OCT-A (superficial vascular complex slab). Based on a nerve fiber trajectory model, each VF test spot was assigned to an OCT-A wedge and an OCT ring-sector. Two univariate linear models (Mv and Mt) using either CD-based vascular (Mv) or RNFL-T–based thickness information (Mt) and one multivariate model using both (Mv:t) were compared in their associations with measured focal VFD, which were higher for the multivariate model Mv:t (mean ± SD correlation coefficient: 0.710 ± 0.086) than for either nested model (0.627 ± 0.078 for Mv and 0.578 ± 0.095 for Mt). Using a focal visual field approach, the combination of RNFL-T and CD showed better structure–function correlations than thickness or vascular information only.

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Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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