Comment on "Widespread RNA and DNA sequence differences in the human transcriptome"

Wei Lin; Robert Piskol; Meng How Tan; Jin Billy Li

doi:10.1126/science.1210624

Comment on "Widespread RNA and DNA sequence differences in the human transcriptome"

Wei Lin, Robert Piskol, Meng How Tan, Jin Billy Li^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › peer-review

76 Citations (Scopus)

Abstract

Li et al. (Research Articles, 1 July 2011, p. 53; published online 19 May 2011) reported widespread differences between the RNA and DNA sequences of the same human cells, including all 12 possible mismatch types. Before accepting such a fundamental claim, a deeper analysis of the sequencing data is required to discern true differences between RNA and DNA from potential artifacts.

Original language	English
Pages (from-to)	1302-e
Journal	Science
Volume	335
Issue number	6074
DOIs	https://doi.org/10.1126/science.1210624
Publication status	Published - Mar 16 2012
Externally published	Yes

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abstract = "Li et al. (Research Articles, 1 July 2011, p. 53; published online 19 May 2011) reported widespread differences between the RNA and DNA sequences of the same human cells, including all 12 possible mismatch types. Before accepting such a fundamental claim, a deeper analysis of the sequencing data is required to discern true differences between RNA and DNA from potential artifacts.",

author = "Wei Lin and Robert Piskol and Tan, {Meng How} and Li, {Jin Billy}",

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AU - Piskol, Robert

AU - Tan, Meng How

AU - Li, Jin Billy

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Y1 - 2012/3/16

N2 - Li et al. (Research Articles, 1 July 2011, p. 53; published online 19 May 2011) reported widespread differences between the RNA and DNA sequences of the same human cells, including all 12 possible mismatch types. Before accepting such a fundamental claim, a deeper analysis of the sequencing data is required to discern true differences between RNA and DNA from potential artifacts.

AB - Li et al. (Research Articles, 1 July 2011, p. 53; published online 19 May 2011) reported widespread differences between the RNA and DNA sequences of the same human cells, including all 12 possible mismatch types. Before accepting such a fundamental claim, a deeper analysis of the sequencing data is required to discern true differences between RNA and DNA from potential artifacts.

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DO - 10.1126/science.1210624

M3 - Comment/debate

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Comment on "Widespread RNA and DNA sequence differences in the human transcriptome"

Abstract

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