TY - JOUR
T1 - Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum
AU - Wilson, R. J.M.(Iain)
AU - Denny, Paul W.
AU - Preiser, Peter R.
AU - Rangachari, Kaveri
AU - Roberts, Kate
AU - Roy, Anjana
AU - Whyte, Andrea
AU - Strath, Malcolm
AU - Moore, Daphne J.
AU - Moore, Peter W.
AU - Williamson, Donald H.
PY - 1996/8/16
Y1 - 1996/8/16
N2 - Malaria parasites, and other parasitic protists of the Phylum Apicomplexa, carry a plastid-like genome with greatly reduced sequence complexity. This 35 kb DNA circle resembles the plastid DNA of non-photosynthetic plants, encoding almost exclusively components involved in gene expression. The complete gene map described here includes genes for duplicated large and small subunit rRNAs, 25 species of tRNA, three subunits of a eubacterial RNA polymerase, 17 ribosomal proteins, and a translation elongation factor. In addition, it codes for an unusual member of the Clp family of chaperones, as well as an open reading frame of unknown function found in red algal plastids. Transcription is polycistronic. This plastid-like DNA molecule is conserved in several genera of apicomplexans and is conjectured to have been acquired by an early progenitor of the Phylum by secondary endosymbiosis. The function of the organelle (plastid) carrying this DNA remains obscure, but appears to be specified by genes transferred to the nucleus.
AB - Malaria parasites, and other parasitic protists of the Phylum Apicomplexa, carry a plastid-like genome with greatly reduced sequence complexity. This 35 kb DNA circle resembles the plastid DNA of non-photosynthetic plants, encoding almost exclusively components involved in gene expression. The complete gene map described here includes genes for duplicated large and small subunit rRNAs, 25 species of tRNA, three subunits of a eubacterial RNA polymerase, 17 ribosomal proteins, and a translation elongation factor. In addition, it codes for an unusual member of the Clp family of chaperones, as well as an open reading frame of unknown function found in red algal plastids. Transcription is polycistronic. This plastid-like DNA molecule is conserved in several genera of apicomplexans and is conjectured to have been acquired by an early progenitor of the Phylum by secondary endosymbiosis. The function of the organelle (plastid) carrying this DNA remains obscure, but appears to be specified by genes transferred to the nucleus.
KW - Evolution
KW - Malaria
KW - Non-photosynthetic plastids
KW - Plastid DNA
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U2 - 10.1006/jmbi.1996.0449
DO - 10.1006/jmbi.1996.0449
M3 - Article
C2 - 8757284
AN - SCOPUS:0030590259
SN - 0022-2836
VL - 261
SP - 155
EP - 172
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
IS - 2
ER -
