Conjugated polyelectrolyte-cisplatin complex nanoparticles for simultaneous in vivo imaging and drug tracking

Dan Ding; Kai Li; Zhenshu Zhu; Kan Yi Pu; Yong Hu; Xiqun Jiang; Bin Liu

doi:10.1039/c0nr00950d

Conjugated polyelectrolyte-cisplatin complex nanoparticles for simultaneous in vivo imaging and drug tracking

Dan Ding, Kai Li, Zhenshu Zhu, Kan Yi Pu, Yong Hu, Xiqun Jiang, Bin Liu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

99 Citations (Scopus)

Abstract

A molecular brush based on conjugated polyelectrolyte (CPE) grafted with dense poly(ethylene glycol) (PEG) chains was successfully complexed with an anticancer agent, cisplatin, to form cisplatin-loaded nanoparticles (CPE-PEG-Pt). The obtained nanoparticles have high far-red/near-infrared fluorescence and are able to release the drug in a continuous and slow manner. These nanoparticles have not only been used to visualize HepG2 cancer cells, but also served as an in vivo fluorescent imaging probe that simultaneously tracks the in vivo drug distribution in nude mice upon intravenous administration.

Original language	English
Pages (from-to)	1997-2002
Number of pages	6
Journal	Nanoscale
Volume	3
Issue number	5
DOIs	https://doi.org/10.1039/c0nr00950d
Publication status	Published - May 2011
Externally published	Yes

ASJC Scopus Subject Areas

General Materials Science

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "A molecular brush based on conjugated polyelectrolyte (CPE) grafted with dense poly(ethylene glycol) (PEG) chains was successfully complexed with an anticancer agent, cisplatin, to form cisplatin-loaded nanoparticles (CPE-PEG-Pt). The obtained nanoparticles have high far-red/near-infrared fluorescence and are able to release the drug in a continuous and slow manner. These nanoparticles have not only been used to visualize HepG2 cancer cells, but also served as an in vivo fluorescent imaging probe that simultaneously tracks the in vivo drug distribution in nude mice upon intravenous administration.",

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AU - Zhu, Zhenshu

AU - Pu, Kan Yi

AU - Hu, Yong

AU - Jiang, Xiqun

AU - Liu, Bin

PY - 2011/5

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AB - A molecular brush based on conjugated polyelectrolyte (CPE) grafted with dense poly(ethylene glycol) (PEG) chains was successfully complexed with an anticancer agent, cisplatin, to form cisplatin-loaded nanoparticles (CPE-PEG-Pt). The obtained nanoparticles have high far-red/near-infrared fluorescence and are able to release the drug in a continuous and slow manner. These nanoparticles have not only been used to visualize HepG2 cancer cells, but also served as an in vivo fluorescent imaging probe that simultaneously tracks the in vivo drug distribution in nude mice upon intravenous administration.

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Conjugated polyelectrolyte-cisplatin complex nanoparticles for simultaneous in vivo imaging and drug tracking

Abstract

ASJC Scopus Subject Areas

UN SDGs

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