Copper-catalyzed α-amination of aliphatic aldehydes

Jie Sheng Tian; Teck Peng Loh

doi:10.1039/c1cc11102g

Copper-catalyzed α-amination of aliphatic aldehydes

Jie Sheng Tian, Teck Peng Loh^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

A highly efficient copper-catalyzed α-amination of aliphatic aldehydes for the synthesis of α-amino acetals using secondary amines with readily removable protecting groups as a nitrogen source was developed. This reaction can be operated under very mild conditions, affording the desired products in moderate to good yields.

Original language	English
Pages (from-to)	5458-5460
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	19
DOIs	https://doi.org/10.1039/c1cc11102g
Publication status	Published - Apr 26 2011
Externally published	Yes

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c1cc11102g

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title = "Copper-catalyzed α-amination of aliphatic aldehydes",

abstract = "A highly efficient copper-catalyzed α-amination of aliphatic aldehydes for the synthesis of α-amino acetals using secondary amines with readily removable protecting groups as a nitrogen source was developed. This reaction can be operated under very mild conditions, affording the desired products in moderate to good yields.",

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AB - A highly efficient copper-catalyzed α-amination of aliphatic aldehydes for the synthesis of α-amino acetals using secondary amines with readily removable protecting groups as a nitrogen source was developed. This reaction can be operated under very mild conditions, affording the desired products in moderate to good yields.

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Copper-catalyzed α-amination of aliphatic aldehydes

Abstract

ASJC Scopus Subject Areas

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