Copper-catalyzed aerobic [3+2]-annulation of N -alkenyl amidines

Yi Feng Wang; Xu Zhu; Shunsuke Chiba

doi:10.1021/ja2120629

Copper-catalyzed aerobic [3+2]-annulation of N -alkenyl amidines

Yi Feng Wang, Xu Zhu, Shunsuke Chiba^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

171 Citations (Scopus)

Abstract

A method for the synthesis of bi- and tricyclic amidines has been developed through copper-catalyzed aerobic [3+2]-annulation reaction of N-alkenyl amidines. These cyclic amidines could be converted into mono-benzyl-protected vicinal diamines by the reduction with aluminum hydride.

Original language	English
Pages (from-to)	3679-3682
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	134
Issue number	8
DOIs	https://doi.org/10.1021/ja2120629
Publication status	Published - Feb 29 2012
Externally published	Yes

ASJC Scopus Subject Areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja2120629

Cite this

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abstract = "A method for the synthesis of bi- and tricyclic amidines has been developed through copper-catalyzed aerobic [3+2]-annulation reaction of N-alkenyl amidines. These cyclic amidines could be converted into mono-benzyl-protected vicinal diamines by the reduction with aluminum hydride.",

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AU - Zhu, Xu

AU - Chiba, Shunsuke

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N2 - A method for the synthesis of bi- and tricyclic amidines has been developed through copper-catalyzed aerobic [3+2]-annulation reaction of N-alkenyl amidines. These cyclic amidines could be converted into mono-benzyl-protected vicinal diamines by the reduction with aluminum hydride.

AB - A method for the synthesis of bi- and tricyclic amidines has been developed through copper-catalyzed aerobic [3+2]-annulation reaction of N-alkenyl amidines. These cyclic amidines could be converted into mono-benzyl-protected vicinal diamines by the reduction with aluminum hydride.

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Copper-catalyzed aerobic [3+2]-annulation of N -alkenyl amidines

Abstract

ASJC Scopus Subject Areas

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