Copper-catalyzed aerobic spirocyclization of biaryl-N-H-imines via 1,4-aminooxygenation of benzene rings

Ya Lin Tnay; Cheng Chen; Yi Yuan Chua; Line Zhang; Shunsuke Chiba

doi:10.1021/ol301583y

Copper-catalyzed aerobic spirocyclization of biaryl-N-H-imines via 1,4-aminooxygenation of benzene rings

Ya Lin Tnay, Cheng Chen, Yi Yuan Chua, Line Zhang, Shunsuke Chiba^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

A synthetic method of azaspirocyclohexadienones has been developed through copper-catalyzed aerobic spirocyclization of biaryl-N-H-imines prepared by the reaction of biarylcarbonitriles and Grignard reagents.

Original language	English
Pages (from-to)	3550-3553
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	13
DOIs	https://doi.org/10.1021/ol301583y
Publication status	Published - Jul 6 2012
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol301583y

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title = "Copper-catalyzed aerobic spirocyclization of biaryl-N-H-imines via 1,4-aminooxygenation of benzene rings",

abstract = "A synthetic method of azaspirocyclohexadienones has been developed through copper-catalyzed aerobic spirocyclization of biaryl-N-H-imines prepared by the reaction of biarylcarbonitriles and Grignard reagents.",

author = "Tnay, \{Ya Lin\} and Cheng Chen and Chua, \{Yi Yuan\} and Line Zhang and Shunsuke Chiba",

year = "2012",

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day = "6",

doi = "10.1021/ol301583y",

language = "English",

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journal = "Organic Letters",

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T1 - Copper-catalyzed aerobic spirocyclization of biaryl-N-H-imines via 1,4-aminooxygenation of benzene rings

AU - Tnay, Ya Lin

AU - Chen, Cheng

AU - Chua, Yi Yuan

AU - Zhang, Line

AU - Chiba, Shunsuke

PY - 2012/7/6

Y1 - 2012/7/6

N2 - A synthetic method of azaspirocyclohexadienones has been developed through copper-catalyzed aerobic spirocyclization of biaryl-N-H-imines prepared by the reaction of biarylcarbonitriles and Grignard reagents.

AB - A synthetic method of azaspirocyclohexadienones has been developed through copper-catalyzed aerobic spirocyclization of biaryl-N-H-imines prepared by the reaction of biarylcarbonitriles and Grignard reagents.

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U2 - 10.1021/ol301583y

DO - 10.1021/ol301583y

M3 - Article

C2 - 22702395

AN - SCOPUS:84863634797

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JO - Organic Letters

JF - Organic Letters

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ER -

Copper-catalyzed aerobic spirocyclization of biaryl-N-H-imines via 1,4-aminooxygenation of benzene rings

Abstract

ASJC Scopus Subject Areas

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