Copper-catalyzed aliphatic C-H amination with an amidine moiety

Hui Chen; Stephen Sanjaya; Yi Feng Wang; Shunsuke Chiba

doi:10.1021/ol303302r

Copper-catalyzed aliphatic C-H amination with an amidine moiety

Hui Chen, Stephen Sanjaya, Yi Feng Wang, Shunsuke Chiba^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

96 Citations (Scopus)

Abstract

A method for amination of aliphatic C-H bonds of N-alkylamidines is described that utilizes Cu(OAc)₂ as the catalyst in the presence of PhI(OAc)₂ and K₃PO₄. The resulting products, dihydroimidazoles and tetrahydropyrimidines, could be converted into the corresponding diamines by hydride reduction.

Original language	English
Pages (from-to)	212-215
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	1
DOIs	https://doi.org/10.1021/ol303302r
Publication status	Published - Jan 4 2013
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol303302r

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title = "Copper-catalyzed aliphatic C-H amination with an amidine moiety",

abstract = "A method for amination of aliphatic C-H bonds of N-alkylamidines is described that utilizes Cu(OAc)2 as the catalyst in the presence of PhI(OAc)2 and K3PO4. The resulting products, dihydroimidazoles and tetrahydropyrimidines, could be converted into the corresponding diamines by hydride reduction.",

author = "Hui Chen and Stephen Sanjaya and Wang, {Yi Feng} and Shunsuke Chiba",

year = "2013",

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doi = "10.1021/ol303302r",

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journal = "Organic Letters",

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T1 - Copper-catalyzed aliphatic C-H amination with an amidine moiety

AU - Chen, Hui

AU - Sanjaya, Stephen

AU - Wang, Yi Feng

AU - Chiba, Shunsuke

PY - 2013/1/4

Y1 - 2013/1/4

N2 - A method for amination of aliphatic C-H bonds of N-alkylamidines is described that utilizes Cu(OAc)2 as the catalyst in the presence of PhI(OAc)2 and K3PO4. The resulting products, dihydroimidazoles and tetrahydropyrimidines, could be converted into the corresponding diamines by hydride reduction.

AB - A method for amination of aliphatic C-H bonds of N-alkylamidines is described that utilizes Cu(OAc)2 as the catalyst in the presence of PhI(OAc)2 and K3PO4. The resulting products, dihydroimidazoles and tetrahydropyrimidines, could be converted into the corresponding diamines by hydride reduction.

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DO - 10.1021/ol303302r

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JO - Organic Letters

JF - Organic Letters

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ER -

Copper-catalyzed aliphatic C-H amination with an amidine moiety

Abstract

ASJC Scopus Subject Areas

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