Copper-catalyzed highly regioselective silylcupration of terminal alkynes to form α-vinylsilanes

Peng Wang; Xue Liang Yeo; Teck Peng Loh

doi:10.1021/ja109464u

Copper-catalyzed highly regioselective silylcupration of terminal alkynes to form α-vinylsilanes

Peng Wang, Xue Liang Yeo, Teck Peng Loh^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

117 Citations (Scopus)

Abstract

A highly regioselective synthesis of branched vinylsilanes through silicon-copper additions to terminal alkynes catalyzed by copper(I) was developed using methanol as additive. The corresponding vinylsilanes were obtained with excellent branched to linear selectivity of up to 99/1 in good yields.

Original language	English
Pages (from-to)	1254-1256
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	133
Issue number	5
DOIs	https://doi.org/10.1021/ja109464u
Publication status	Published - Feb 9 2011
Externally published	Yes

ASJC Scopus Subject Areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja109464u

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title = "Copper-catalyzed highly regioselective silylcupration of terminal alkynes to form α-vinylsilanes",

abstract = "A highly regioselective synthesis of branched vinylsilanes through silicon-copper additions to terminal alkynes catalyzed by copper(I) was developed using methanol as additive. The corresponding vinylsilanes were obtained with excellent branched to linear selectivity of up to 99/1 in good yields.",

author = "Peng Wang and Yeo, {Xue Liang} and Loh, {Teck Peng}",

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AU - Yeo, Xue Liang

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Y1 - 2011/2/9

N2 - A highly regioselective synthesis of branched vinylsilanes through silicon-copper additions to terminal alkynes catalyzed by copper(I) was developed using methanol as additive. The corresponding vinylsilanes were obtained with excellent branched to linear selectivity of up to 99/1 in good yields.

AB - A highly regioselective synthesis of branched vinylsilanes through silicon-copper additions to terminal alkynes catalyzed by copper(I) was developed using methanol as additive. The corresponding vinylsilanes were obtained with excellent branched to linear selectivity of up to 99/1 in good yields.

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Copper-catalyzed highly regioselective silylcupration of terminal alkynes to form α-vinylsilanes

Abstract

ASJC Scopus Subject Areas

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