Copper-catalyzed rearrangement of tertiary amines through oxidation of aliphatic C-H bonds in air or oxygen: Direct synthesis of α-amino acetals

Jie Sheng Tian; Teck Peng Loh

doi:10.1002/anie.201003646

Copper-catalyzed rearrangement of tertiary amines through oxidation of aliphatic C-H bonds in air or oxygen: Direct synthesis of α-amino acetals

Jie Sheng Tian^*, Teck Peng Loh

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

98 Citations (Scopus)

Abstract

A surprising turn of events: Mechanistic studies, including trapping, control, and isotope-labeling experiments, led to the proposal of a rearrangement mechanism involving oxidation of aliphatic C-H bonds (see scheme; TMEDA=tetramethylethylenediamine).

Original language	English
Pages (from-to)	8417-8420
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	45
DOIs	https://doi.org/10.1002/anie.201003646
Publication status	Published - Nov 2 2010
Externally published	Yes

ASJC Scopus Subject Areas

Catalysis
General Chemistry

Keywords

α-amino acetals
Copper
Oxidative rearrangement
Oxygen
Tertiary amines

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abstract = "A surprising turn of events: Mechanistic studies, including trapping, control, and isotope-labeling experiments, led to the proposal of a rearrangement mechanism involving oxidation of aliphatic C-H bonds (see scheme; TMEDA=tetramethylethylenediamine).",

keywords = "α-amino acetals, Copper, Oxidative rearrangement, Oxygen, Tertiary amines",

author = "Tian, {Jie Sheng} and Loh, {Teck Peng}",

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AU - Loh, Teck Peng

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Y1 - 2010/11/2

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KW - Copper

KW - Oxidative rearrangement

KW - Oxygen

KW - Tertiary amines

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Copper-catalyzed rearrangement of tertiary amines through oxidation of aliphatic C-H bonds in air or oxygen: Direct synthesis of α-amino acetals

Abstract

ASJC Scopus Subject Areas

Keywords

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