Copper-catalyzed three-component cyclization of amidines, styrenes, and fluoroalkyl halides for the synthesis of modular fluoroalkylated pyrimidines

Xue Qiang Chu; Bu Qing Cheng; Yao Wei Zhang; Danhua Ge; Zhi Liang Shen; Teck Peng Loh

doi:10.1039/c7cc09571f

Copper-catalyzed three-component cyclization of amidines, styrenes, and fluoroalkyl halides for the synthesis of modular fluoroalkylated pyrimidines

Xue Qiang Chu, Bu Qing Cheng, Yao Wei Zhang, Danhua Ge, Zhi Liang Shen^*, Teck Peng Loh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

An efficient copper-catalyzed three-component cyclization for the construction of highly functionalized pyrimidine derivatives from readily available amidines, styrenes and fluoroalkyl halides is developed. This protocol distinguishes itself by the formation of three new C-C/C-N bonds and a new six-membered ring through a radical addition/oxidation/cyclization sequence in a one-pot manner.

Original language	English
Pages (from-to)	2615-2618
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	21
DOIs	https://doi.org/10.1039/c7cc09571f
Publication status	Published - 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 The Royal Society of Chemistry.

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c7cc09571f

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abstract = "An efficient copper-catalyzed three-component cyclization for the construction of highly functionalized pyrimidine derivatives from readily available amidines, styrenes and fluoroalkyl halides is developed. This protocol distinguishes itself by the formation of three new C-C/C-N bonds and a new six-membered ring through a radical addition/oxidation/cyclization sequence in a one-pot manner.",

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AU - Chu, Xue Qiang

AU - Cheng, Bu Qing

AU - Zhang, Yao Wei

AU - Ge, Danhua

AU - Shen, Zhi Liang

AU - Loh, Teck Peng

PY - 2018

Y1 - 2018

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AB - An efficient copper-catalyzed three-component cyclization for the construction of highly functionalized pyrimidine derivatives from readily available amidines, styrenes and fluoroalkyl halides is developed. This protocol distinguishes itself by the formation of three new C-C/C-N bonds and a new six-membered ring through a radical addition/oxidation/cyclization sequence in a one-pot manner.

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Copper-catalyzed three-component cyclization of amidines, styrenes, and fluoroalkyl halides for the synthesis of modular fluoroalkylated pyrimidines

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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