Copper-catalyzed trifluoromethylation of styrene derivatives with CF3SO2Na

Liu Hai Wu; Kai Zhao; Zhi Liang Shen; Teck Peng Loh

doi:10.1039/c7qo00416h

Copper-catalyzed trifluoromethylation of styrene derivatives with CF₃SO₂Na

Liu Hai Wu, Kai Zhao, Zhi Liang Shen^*, Teck Peng Loh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

An efficient copper(i)-catalyzed trifluoromethylation of styrene derivatives using CF₃SO₂Na as a trifluoromethylating source in the presence of ^tBuOO^tBu has been developed. Mechanistic studies show that the reaction likely proceeds via a radical pathway, providing a general and straightforward access to trifluoromethylated styrene derivatives. Advantageously, excellent stereoselectivity is obtained with styrene derivatives in this transformation.

Original language	English
Pages (from-to)	1872-1875
Number of pages	4
Journal	Organic Chemistry Frontiers
Volume	4
Issue number	9
DOIs	https://doi.org/10.1039/c7qo00416h
Publication status	Published - Sept 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 the Partner Organisations.

ASJC Scopus Subject Areas

Organic Chemistry

Access to Document

10.1039/c7qo00416h

Cite this

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