Copper-Catalyzed Vicinal Oxyazidation and Diazidation of Styrenes under Mild Conditions: Access to Alkyl Azides

Ming Zhu Lu; Cheng Qiang Wang; Teck Peng Loh

doi:10.1021/acs.orglett.5b03130

Copper-Catalyzed Vicinal Oxyazidation and Diazidation of Styrenes under Mild Conditions: Access to Alkyl Azides

Ming Zhu Lu, Cheng Qiang Wang, Teck Peng Loh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

108 Citations (Scopus)

Abstract

A novel and efficient copper-catalyzed oxyazidation and diazidation of styrenes is described. The stable azidoiodine(III) reagent is used as an efficient azide radical source in this reaction. A variety of synthetically useful functional groups are compatible with the mild reaction conditions. This protocol enables the straightforward synthesis of various functionalized azides in good-to-excellent yields.

Original language	English
Pages (from-to)	6110-6113
Number of pages	4
Journal	Organic Letters
Volume	17
Issue number	24
DOIs	https://doi.org/10.1021/acs.orglett.5b03130
Publication status	Published - Dec 18 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 American Chemical Society.

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "A novel and efficient copper-catalyzed oxyazidation and diazidation of styrenes is described. The stable azidoiodine(III) reagent is used as an efficient azide radical source in this reaction. A variety of synthetically useful functional groups are compatible with the mild reaction conditions. This protocol enables the straightforward synthesis of various functionalized azides in good-to-excellent yields.",

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AU - Loh, Teck Peng

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Y1 - 2015/12/18

N2 - A novel and efficient copper-catalyzed oxyazidation and diazidation of styrenes is described. The stable azidoiodine(III) reagent is used as an efficient azide radical source in this reaction. A variety of synthetically useful functional groups are compatible with the mild reaction conditions. This protocol enables the straightforward synthesis of various functionalized azides in good-to-excellent yields.

AB - A novel and efficient copper-catalyzed oxyazidation and diazidation of styrenes is described. The stable azidoiodine(III) reagent is used as an efficient azide radical source in this reaction. A variety of synthetically useful functional groups are compatible with the mild reaction conditions. This protocol enables the straightforward synthesis of various functionalized azides in good-to-excellent yields.

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Copper-Catalyzed Vicinal Oxyazidation and Diazidation of Styrenes under Mild Conditions: Access to Alkyl Azides

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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