Correlation between membrane partitioning and functional activity in a single lipid vesicle assay establishes design guidelines for antiviral peptides

Joshua A. Jackman; Rathi Saravanan; Yibang Zhang; Seyed R. Tabaei; Nam Joon Cho

doi:10.1002/smll.201403638

Correlation between membrane partitioning and functional activity in a single lipid vesicle assay establishes design guidelines for antiviral peptides

Joshua A. Jackman, Rathi Saravanan, Yibang Zhang, Seyed R. Tabaei, Nam Joon Cho^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

The nanometer-scale discrimination of virus-rupturing peptides is tested using lipid membrane platforms. In combination with single-vesicle analysis of peptide-induced vesicle rupture, a correlation between membrane partitioning and biologically relevant activities is established. Taken together, the findings support that the degree of rupture activity should be balanced by membrane curvature-selectivity for optimal therapeutic properties of antiviral peptides.

Original language	English
Pages (from-to)	2372-2379
Number of pages	8
Journal	Small
Volume	11
Issue number	20
DOIs	https://doi.org/10.1002/smll.201403638
Publication status	Published - May 27 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

ASJC Scopus Subject Areas

Biotechnology
General Chemistry
Biomaterials
General Materials Science
Engineering (miscellaneous)

Keywords

antiviral agents
nanomedicine
peptides
structure-property relationships
vesicles

Access to Document

10.1002/smll.201403638

Cite this

@article{dff3b8b9d8a041bda79f50674b74719d,

title = "Correlation between membrane partitioning and functional activity in a single lipid vesicle assay establishes design guidelines for antiviral peptides",

abstract = "The nanometer-scale discrimination of virus-rupturing peptides is tested using lipid membrane platforms. In combination with single-vesicle analysis of peptide-induced vesicle rupture, a correlation between membrane partitioning and biologically relevant activities is established. Taken together, the findings support that the degree of rupture activity should be balanced by membrane curvature-selectivity for optimal therapeutic properties of antiviral peptides.",

keywords = "antiviral agents, nanomedicine, peptides, structure-property relationships, vesicles",

author = "Jackman, {Joshua A.} and Rathi Saravanan and Yibang Zhang and Tabaei, {Seyed R.} and Cho, {Nam Joon}",

note = "Publisher Copyright: {\textcopyright} 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2015",

month = may,

day = "27",

doi = "10.1002/smll.201403638",

language = "English",

volume = "11",

pages = "2372--2379",

journal = "Small",

issn = "1613-6810",

publisher = "Wiley-VCH Verlag",

number = "20",

}

TY - JOUR

T1 - Correlation between membrane partitioning and functional activity in a single lipid vesicle assay establishes design guidelines for antiviral peptides

AU - Jackman, Joshua A.

AU - Saravanan, Rathi

AU - Zhang, Yibang

AU - Tabaei, Seyed R.

AU - Cho, Nam Joon

PY - 2015/5/27

Y1 - 2015/5/27

N2 - The nanometer-scale discrimination of virus-rupturing peptides is tested using lipid membrane platforms. In combination with single-vesicle analysis of peptide-induced vesicle rupture, a correlation between membrane partitioning and biologically relevant activities is established. Taken together, the findings support that the degree of rupture activity should be balanced by membrane curvature-selectivity for optimal therapeutic properties of antiviral peptides.

AB - The nanometer-scale discrimination of virus-rupturing peptides is tested using lipid membrane platforms. In combination with single-vesicle analysis of peptide-induced vesicle rupture, a correlation between membrane partitioning and biologically relevant activities is established. Taken together, the findings support that the degree of rupture activity should be balanced by membrane curvature-selectivity for optimal therapeutic properties of antiviral peptides.

KW - antiviral agents

KW - nanomedicine

KW - peptides

KW - structure-property relationships

KW - vesicles

UR - http://www.scopus.com/inward/record.url?scp=84929578584&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929578584&partnerID=8YFLogxK

U2 - 10.1002/smll.201403638

DO - 10.1002/smll.201403638

M3 - Article

C2 - 25619175

AN - SCOPUS:84929578584

SN - 1613-6810

VL - 11

SP - 2372

EP - 2379

JO - Small

JF - Small

IS - 20

ER -

Correlation between membrane partitioning and functional activity in a single lipid vesicle assay establishes design guidelines for antiviral peptides

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

Other files and links

Fingerprint

Cite this