DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes

Atish Kizhakeyil; Nurmahirah Binte Mohammed Zaini; Zhi Sheng Poh; Brandon Han Siang Wong; Xinpeng Loh; Aik Seng Ng; Zun Siong Low; Praseetha Prasannan; Chun Gong; Michelle Guet Khim Tan; Chandramouli Nagarajan; Dachuan Huang; Pang Wan Lu; Jing Quan Lim; Sharon Barrans; Choon Kiat Ong; Soon Thye Lim; Wee Joo Chng; George Follows; Daniel J. Hodson; Ming Qing Du; Yeow Tee Goh; Suat Hoon Tan; Nicholas Francis Grigoropoulos; Navin Kumar Verma

doi:10.1186/s12943-021-01437-0

DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes

Atish Kizhakeyil, Nurmahirah Binte Mohammed Zaini, Zhi Sheng Poh, Brandon Han Siang Wong, Xinpeng Loh, Aik Seng Ng, Zun Siong Low, Praseetha Prasannan, Chun Gong, Michelle Guet Khim Tan, Chandramouli Nagarajan, Dachuan Huang, Pang Wan Lu, Jing Quan Lim, Sharon Barrans, Choon Kiat Ong, Soon Thye Lim, Wee Joo Chng, George Follows, Daniel J. HodsonMing Qing Du, Yeow Tee Goh, Suat Hoon Tan, Nicholas Francis Grigoropoulos^*, Navin Kumar Verma^*

^*Corresponding author for this work

10 Citations (Scopus)

Original language	English
Article number	134
Journal	Molecular Cancer
Volume	20
Issue number	1
DOIs	https://doi.org/10.1186/s12943-021-01437-0
Publication status	Published - Dec 2021
Externally published	Yes

ASJC Scopus Subject Areas

Molecular Medicine
Oncology
Cancer Research

Keywords

DDX3X mutation
Drug resistance
Hematolymphoid malignancy
Prognosis
Tumour metastasis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s12943-021-01437-0

Cite this

Kizhakeyil, A., Zaini, N. B. M., Poh, Z. S., Wong, B. H. S., Loh, X., Ng, A. S., Low, Z. S., Prasannan, P., Gong, C., Tan, M. G. K., Nagarajan, C., Huang, D., Lu, P. W., Lim, J. Q., Barrans, S., Ong, C. K., Lim, S. T., Chng, W. J., Follows, G., ... Verma, N. K. (2021). DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes. Molecular Cancer, 20(1), Article 134. https://doi.org/10.1186/s12943-021-01437-0

@article{2b2e4a1454cb45dbbe6c7aec5d6daf1d,

title = "DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes",

keywords = "DDX3X mutation, Drug resistance, Hematolymphoid malignancy, Prognosis, Tumour metastasis",

author = "Atish Kizhakeyil and Zaini, {Nurmahirah Binte Mohammed} and Poh, {Zhi Sheng} and Wong, {Brandon Han Siang} and Xinpeng Loh and Ng, {Aik Seng} and Low, {Zun Siong} and Praseetha Prasannan and Chun Gong and Tan, {Michelle Guet Khim} and Chandramouli Nagarajan and Dachuan Huang and Lu, {Pang Wan} and Lim, {Jing Quan} and Sharon Barrans and Ong, {Choon Kiat} and Lim, {Soon Thye} and Chng, {Wee Joo} and George Follows and Hodson, {Daniel J.} and Du, {Ming Qing} and Goh, {Yeow Tee} and Tan, {Suat Hoon} and Grigoropoulos, {Nicholas Francis} and Verma, {Navin Kumar}",

year = "2021",

month = dec,

doi = "10.1186/s12943-021-01437-0",

language = "English",

volume = "20",

journal = "Molecular Cancer",

issn = "1476-4598",

publisher = "BioMed Central",

number = "1",

}

Kizhakeyil, A, Zaini, NBM, Poh, ZS, Wong, BHS, Loh, X, Ng, AS, Low, ZS, Prasannan, P, Gong, C, Tan, MGK, Nagarajan, C, Huang, D, Lu, PW, Lim, JQ, Barrans, S, Ong, CK, Lim, ST, Chng, WJ, Follows, G, Hodson, DJ, Du, MQ, Goh, YT, Tan, SH, Grigoropoulos, NF & Verma, NK 2021, 'DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes', Molecular Cancer, vol. 20, no. 1, 134. https://doi.org/10.1186/s12943-021-01437-0

TY - JOUR

T1 - DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes

AU - Kizhakeyil, Atish

AU - Zaini, Nurmahirah Binte Mohammed

AU - Poh, Zhi Sheng

AU - Wong, Brandon Han Siang

AU - Loh, Xinpeng

AU - Ng, Aik Seng

AU - Low, Zun Siong

AU - Prasannan, Praseetha

AU - Gong, Chun

AU - Tan, Michelle Guet Khim

AU - Nagarajan, Chandramouli

AU - Huang, Dachuan

AU - Lu, Pang Wan

AU - Lim, Jing Quan

AU - Barrans, Sharon

AU - Ong, Choon Kiat

AU - Lim, Soon Thye

AU - Chng, Wee Joo

AU - Follows, George

AU - Hodson, Daniel J.

AU - Du, Ming Qing

AU - Goh, Yeow Tee

AU - Tan, Suat Hoon

AU - Grigoropoulos, Nicholas Francis

AU - Verma, Navin Kumar

PY - 2021/12

Y1 - 2021/12

KW - DDX3X mutation

KW - Drug resistance

KW - Hematolymphoid malignancy

KW - Prognosis

KW - Tumour metastasis

UR - http://www.scopus.com/inward/record.url?scp=85117353882&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85117353882&partnerID=8YFLogxK

U2 - 10.1186/s12943-021-01437-0

DO - 10.1186/s12943-021-01437-0

M3 - Letter

C2 - 34654425

AN - SCOPUS:85117353882

SN - 1476-4598

VL - 20

JO - Molecular Cancer

JF - Molecular Cancer

IS - 1

M1 - 134

ER -

DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes

ASJC Scopus Subject Areas

Keywords

UN SDGs

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Chemotherapy fails for some blood cancer patients because of crucial gene mutations, finds study by NTU Singapore and Singapore General Hospital

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DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes

ASJC Scopus Subject Areas

Keywords

UN SDGs

Access to Document

Other files and links

Press/Media

Chemotherapy fails for some blood cancer patients because of crucial gene mutations, finds study by NTU Singapore and Singapore General Hospital

Cite this