Deciphering the molecular landscape of the FAM72 gene family: Implications for stem cell biology and cancer

Janani Ramesh; Raja Mohan Gopalakrishnan; Tuan Hoang Anh Nguyen; Soak Kuan Lai; Hoi Yeung Li; Pok Son Kim; Arne Kutzner; Noriko Inoue; Klaus Heese

doi:10.1016/j.neuint.2024.105853

Deciphering the molecular landscape of the FAM72 gene family: Implications for stem cell biology and cancer

Janani Ramesh, Raja Mohan Gopalakrishnan, Tuan Hoang Anh Nguyen, Soak Kuan Lai, Hoi Yeung Li, Pok Son Kim, Arne Kutzner, Noriko Inoue, Klaus Heese^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Family with sequence similarity 72 (FAM72) is a protein-coding gene family located on chromosome 1 in humans, uniquely featuring four paralogs: FAM72A, FAM72B, FAM72C, and FAM72D. While FAM72's presence as a gene pair with the SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2) is intriguing, its functional roles, particularly in neural stem cells, remain incompletely understood. This review explores the distinct characteristics of FAM72, shedding light on its expression patterns, potential roles in cell cycle regulation, stem cell renewal and implications in neurogenesis and tumorigenesis.

Original language	English
Article number	105853
Journal	Neurochemistry International
Volume	180
DOIs	https://doi.org/10.1016/j.neuint.2024.105853
Publication status	Published - Nov 2024
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2024 Elsevier Ltd

ASJC Scopus Subject Areas

Cellular and Molecular Neuroscience
Cell Biology

Keywords

Cell cycle
DNA repair
FOXM1
Glioblastoma
Proliferation
Stem cell
UNG

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.neuint.2024.105853

Cite this

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title = "Deciphering the molecular landscape of the FAM72 gene family: Implications for stem cell biology and cancer",

abstract = "Family with sequence similarity 72 (FAM72) is a protein-coding gene family located on chromosome 1 in humans, uniquely featuring four paralogs: FAM72A, FAM72B, FAM72C, and FAM72D. While FAM72's presence as a gene pair with the SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2) is intriguing, its functional roles, particularly in neural stem cells, remain incompletely understood. This review explores the distinct characteristics of FAM72, shedding light on its expression patterns, potential roles in cell cycle regulation, stem cell renewal and implications in neurogenesis and tumorigenesis.",

keywords = "Cell cycle, DNA repair, FOXM1, Glioblastoma, Proliferation, Stem cell, UNG",

author = "Janani Ramesh and Gopalakrishnan, {Raja Mohan} and Nguyen, {Tuan Hoang Anh} and Lai, {Soak Kuan} and Li, {Hoi Yeung} and Kim, {Pok Son} and Arne Kutzner and Noriko Inoue and Klaus Heese",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd",

year = "2024",

month = nov,

doi = "10.1016/j.neuint.2024.105853",

language = "English",

volume = "180",

journal = "Neurochemistry International",

issn = "0197-0186",

publisher = "Elsevier Limited",

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T1 - Deciphering the molecular landscape of the FAM72 gene family

T2 - Implications for stem cell biology and cancer

AU - Ramesh, Janani

AU - Gopalakrishnan, Raja Mohan

AU - Nguyen, Tuan Hoang Anh

AU - Lai, Soak Kuan

AU - Li, Hoi Yeung

AU - Kim, Pok Son

AU - Kutzner, Arne

AU - Inoue, Noriko

AU - Heese, Klaus

PY - 2024/11

Y1 - 2024/11

N2 - Family with sequence similarity 72 (FAM72) is a protein-coding gene family located on chromosome 1 in humans, uniquely featuring four paralogs: FAM72A, FAM72B, FAM72C, and FAM72D. While FAM72's presence as a gene pair with the SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2) is intriguing, its functional roles, particularly in neural stem cells, remain incompletely understood. This review explores the distinct characteristics of FAM72, shedding light on its expression patterns, potential roles in cell cycle regulation, stem cell renewal and implications in neurogenesis and tumorigenesis.

AB - Family with sequence similarity 72 (FAM72) is a protein-coding gene family located on chromosome 1 in humans, uniquely featuring four paralogs: FAM72A, FAM72B, FAM72C, and FAM72D. While FAM72's presence as a gene pair with the SLIT-ROBO Rho GTPase-activating protein 2 (SRGAP2) is intriguing, its functional roles, particularly in neural stem cells, remain incompletely understood. This review explores the distinct characteristics of FAM72, shedding light on its expression patterns, potential roles in cell cycle regulation, stem cell renewal and implications in neurogenesis and tumorigenesis.

KW - Cell cycle

KW - DNA repair

KW - FOXM1

KW - Glioblastoma

KW - Proliferation

KW - Stem cell

KW - UNG

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DO - 10.1016/j.neuint.2024.105853

M3 - Review article

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SN - 0197-0186

VL - 180

JO - Neurochemistry International

JF - Neurochemistry International

M1 - 105853

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Deciphering the molecular landscape of the FAM72 gene family: Implications for stem cell biology and cancer

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

UN SDGs

Access to Document

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