Design and fabrication a microfluidic device for fetal cells dielectrophoretic properties characterization

Guolin Xu; M. B. Chan; Charles Yang; P. Sukumar; M. Choolani; Jackie Y. Ying

doi:10.1088/1742-6596/34/1/182

Design and fabrication a microfluidic device for fetal cells dielectrophoretic properties characterization

Guolin Xu, M. B. Chan, Charles Yang, P. Sukumar, M. Choolani, Jackie Y. Ying^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The present work presents a microfluidic device with interdigitated microelectrode and microchannel for fetal nucleated red blood cell dielectrophoresis properties characterization using crossover frequency method. To obtain the electric field and its gradient along the microchannel, simulation study was done by using MAXWELL software. Results show maximum electric field and gradient are obtained near the electrode edge and they are affected by electrode width and the electrode gap. The crossover frequency should be obtained by keeping the cell moving near the electrode edge. The device has been successfully used in fetal cell characterization with better than 1KHz frequency repeatability, which is about 2% of the measured crossover frequency.

Original language	English
Pages (from-to)	1106-1111
Number of pages	6
Journal	Journal of Physics: Conference Series
Volume	34
Issue number	1
DOIs	https://doi.org/10.1088/1742-6596/34/1/182
Publication status	Published - Apr 1 2006
Externally published	Yes

ASJC Scopus Subject Areas

General Physics and Astronomy

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abstract = "The present work presents a microfluidic device with interdigitated microelectrode and microchannel for fetal nucleated red blood cell dielectrophoresis properties characterization using crossover frequency method. To obtain the electric field and its gradient along the microchannel, simulation study was done by using MAXWELL software. Results show maximum electric field and gradient are obtained near the electrode edge and they are affected by electrode width and the electrode gap. The crossover frequency should be obtained by keeping the cell moving near the electrode edge. The device has been successfully used in fetal cell characterization with better than 1KHz frequency repeatability, which is about 2\% of the measured crossover frequency.",

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AU - Xu, Guolin

AU - Chan, M. B.

AU - Yang, Charles

AU - Sukumar, P.

AU - Choolani, M.

AU - Ying, Jackie Y.

PY - 2006/4/1

Y1 - 2006/4/1

N2 - The present work presents a microfluidic device with interdigitated microelectrode and microchannel for fetal nucleated red blood cell dielectrophoresis properties characterization using crossover frequency method. To obtain the electric field and its gradient along the microchannel, simulation study was done by using MAXWELL software. Results show maximum electric field and gradient are obtained near the electrode edge and they are affected by electrode width and the electrode gap. The crossover frequency should be obtained by keeping the cell moving near the electrode edge. The device has been successfully used in fetal cell characterization with better than 1KHz frequency repeatability, which is about 2% of the measured crossover frequency.

AB - The present work presents a microfluidic device with interdigitated microelectrode and microchannel for fetal nucleated red blood cell dielectrophoresis properties characterization using crossover frequency method. To obtain the electric field and its gradient along the microchannel, simulation study was done by using MAXWELL software. Results show maximum electric field and gradient are obtained near the electrode edge and they are affected by electrode width and the electrode gap. The crossover frequency should be obtained by keeping the cell moving near the electrode edge. The device has been successfully used in fetal cell characterization with better than 1KHz frequency repeatability, which is about 2% of the measured crossover frequency.

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Design and fabrication a microfluidic device for fetal cells dielectrophoretic properties characterization

Abstract

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