Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. Elegans

Caroline Beaudoin-Chabot; Lei Wang; Alexey V. Smarun; Dragoslav Vidović; Mikhail S. Shchepinov; Guillaume Thibault

doi:10.3389/fphys.2019.00641

Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. Elegans

Caroline Beaudoin-Chabot, Lei Wang, Alexey V. Smarun, Dragoslav Vidović, Mikhail S. Shchepinov, Guillaume Thibault^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Chemically reinforced essential fatty acids (FAs) promise to fight numerous age-related diseases including Alzheimer's, Friedreich's ataxia and other neurological conditions. The reinforcement is achieved by substituting the atoms of hydrogen at the bis-allylic methylene of these essential FAs with the isotope deuterium. This substitution leads to a significantly slower oxidation due to the kinetic isotope effect, inhibiting membrane damage. The approach has the advantage of preventing the harmful accumulation of reactive oxygen species (ROS) by inhibiting the propagation of lipid peroxidation while antioxidants potentially neutralize beneficial oxidative species. Here, we developed a model system to mimic the human dietary requirement of omega-3 in Caenorhabditis elegans to study the role of deuterated polyunsaturated fatty acids (D-PUFAs). Deuterated trilinolenin [D-TG(54:9)] was sufficient to prevent the accumulation of lipid peroxides and to reduce the accumulation or ROS. Moreover, D-TG(54:9) significantly extended the lifespan of worms under normal and oxidative stress conditions. These findings demonstrate that D-PUFAs can be used as a food supplement to decelerate the aging process, resulting in extended lifespan.

Original language	English
Article number	641
Journal	Frontiers in Physiology
Volume	10
Issue number	MAY
DOIs	https://doi.org/10.3389/fphys.2019.00641
Publication status	Published - 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2019 Beaudoin-Chabot, Wang, Smarun, Vidović, Shchepinov and Thibault. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

ASJC Scopus Subject Areas

Physiology
Physiology (medical)

Keywords

C. elegans
Deuterated fatty acid
Essential fatty acids
Lifespan
Linolenic acid
Lipid peroxidation
Oxidative stress
Polyunsaturated fatty acid (PUFA)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fphys.2019.00641

Cite this

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title = "Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. Elegans",

abstract = "Chemically reinforced essential fatty acids (FAs) promise to fight numerous age-related diseases including Alzheimer's, Friedreich's ataxia and other neurological conditions. The reinforcement is achieved by substituting the atoms of hydrogen at the bis-allylic methylene of these essential FAs with the isotope deuterium. This substitution leads to a significantly slower oxidation due to the kinetic isotope effect, inhibiting membrane damage. The approach has the advantage of preventing the harmful accumulation of reactive oxygen species (ROS) by inhibiting the propagation of lipid peroxidation while antioxidants potentially neutralize beneficial oxidative species. Here, we developed a model system to mimic the human dietary requirement of omega-3 in Caenorhabditis elegans to study the role of deuterated polyunsaturated fatty acids (D-PUFAs). Deuterated trilinolenin [D-TG(54:9)] was sufficient to prevent the accumulation of lipid peroxides and to reduce the accumulation or ROS. Moreover, D-TG(54:9) significantly extended the lifespan of worms under normal and oxidative stress conditions. These findings demonstrate that D-PUFAs can be used as a food supplement to decelerate the aging process, resulting in extended lifespan.",

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AU - Shchepinov, Mikhail S.

AU - Thibault, Guillaume

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Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. Elegans

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

UN SDGs

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