Diphenylprolinol methyl ether: A highly enantioselective catalyst for Michael addition of aldehydes to simple enones

Yonggui Chi; Samuel H. Gellman

doi:10.1021/ol0517729

Diphenylprolinol methyl ether: A highly enantioselective catalyst for Michael addition of aldehydes to simple enones

Yonggui Chi, Samuel H. Gellman^*

^*Corresponding author for this work

University of Wisconsin-Madison

Research output: Contribution to journal › Article › peer-review

245 Citations (Scopus)

Abstract

(Chemical Equation Presented) Diphenylprolinol methyl ether catalyzes intermolecular Michael addition of simple aldehydes to relatively nonactivated enones with the highest enantioselectivities reported to date (95-99% ee) and significantly lower catalyst loadings than have been typical in this arena.

Original language	English
Pages (from-to)	4253-4256
Number of pages	4
Journal	Organic Letters
Volume	7
Issue number	19
DOIs	https://doi.org/10.1021/ol0517729
Publication status	Published - Sept 15 2005
Externally published	Yes

ASJC Scopus Subject Areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol0517729

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title = "Diphenylprolinol methyl ether: A highly enantioselective catalyst for Michael addition of aldehydes to simple enones",

abstract = "(Chemical Equation Presented) Diphenylprolinol methyl ether catalyzes intermolecular Michael addition of simple aldehydes to relatively nonactivated enones with the highest enantioselectivities reported to date (95-99% ee) and significantly lower catalyst loadings than have been typical in this arena.",

author = "Yonggui Chi and Gellman, {Samuel H.}",

year = "2005",

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AU - Chi, Yonggui

AU - Gellman, Samuel H.

PY - 2005/9/15

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N2 - (Chemical Equation Presented) Diphenylprolinol methyl ether catalyzes intermolecular Michael addition of simple aldehydes to relatively nonactivated enones with the highest enantioselectivities reported to date (95-99% ee) and significantly lower catalyst loadings than have been typical in this arena.

AB - (Chemical Equation Presented) Diphenylprolinol methyl ether catalyzes intermolecular Michael addition of simple aldehydes to relatively nonactivated enones with the highest enantioselectivities reported to date (95-99% ee) and significantly lower catalyst loadings than have been typical in this arena.

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JO - Organic Letters

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Diphenylprolinol methyl ether: A highly enantioselective catalyst for Michael addition of aldehydes to simple enones

Abstract

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