Directing-group-assisted copper-catalyzed olefinic trifluoromethylation of electron-deficient alkenes

Chao Feng; Teck Peng Loh

doi:10.1002/anie.201307245

Directing-group-assisted copper-catalyzed olefinic trifluoromethylation of electron-deficient alkenes

Chao Feng, Teck Peng Loh

Research output: Contribution to journal › Article › peer-review

124 Citations (Scopus)

Abstract

Assistance provided: The directing group in the title reaction not only activates the substrates but also allows the stereospecific formation of cis-trifluoromethylated products. The reaction is operationally simple and tolerates a wide variety of functional groups, thus providing an efficient method for the stereoselective synthesis of β-CF₃-functionalized acrylamide derivatives.

Original language	English
Pages (from-to)	12414-12417
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	47
DOIs	https://doi.org/10.1002/anie.201307245
Publication status	Published - Nov 18 2013
Externally published	Yes

ASJC Scopus Subject Areas

Catalysis
General Chemistry

Keywords

alkenes
C-H activation
copper
cross-coupling
trifluoromethylation

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10.1002/anie.201307245

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abstract = "Assistance provided: The directing group in the title reaction not only activates the substrates but also allows the stereospecific formation of cis-trifluoromethylated products. The reaction is operationally simple and tolerates a wide variety of functional groups, thus providing an efficient method for the stereoselective synthesis of β-CF3-functionalized acrylamide derivatives.",

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author = "Chao Feng and Loh, {Teck Peng}",

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AU - Feng, Chao

AU - Loh, Teck Peng

PY - 2013/11/18

Y1 - 2013/11/18

N2 - Assistance provided: The directing group in the title reaction not only activates the substrates but also allows the stereospecific formation of cis-trifluoromethylated products. The reaction is operationally simple and tolerates a wide variety of functional groups, thus providing an efficient method for the stereoselective synthesis of β-CF3-functionalized acrylamide derivatives.

AB - Assistance provided: The directing group in the title reaction not only activates the substrates but also allows the stereospecific formation of cis-trifluoromethylated products. The reaction is operationally simple and tolerates a wide variety of functional groups, thus providing an efficient method for the stereoselective synthesis of β-CF3-functionalized acrylamide derivatives.

KW - alkenes

KW - C-H activation

KW - copper

KW - cross-coupling

KW - trifluoromethylation

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Directing-group-assisted copper-catalyzed olefinic trifluoromethylation of electron-deficient alkenes

Abstract

ASJC Scopus Subject Areas

Keywords

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