Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin

Zhen Jie Low; Juan Xiong; Ying Xie; Guang Lei Ma; Howard Saw; Hoa Thi Tran; Soo Lin Wong; Li Mei Pang; July Fong; Peng Lu; Jin Feng Hu; Yang Liang; Yansong Miao; Zhao Xun Liang

doi:10.1039/c9cc08908j

Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin

Zhen Jie Low, Juan Xiong, Ying Xie, Guang Lei Ma, Howard Saw, Hoa Thi Tran, Soo Lin Wong, Li Mei Pang, July Fong, Peng Lu, Jin Feng Hu, Yang Liang, Yansong Miao^*, Zhao Xun Liang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Produced by a newly isolated Streptomycetes strain, meijiemycin is a gigantic linear polyene-polyol that exhibits structural features not seen in other members of the polyene-polyol family. We propose a biosynthetic mechanism and demonstrate that meijiemycin inhibits hyphal growth by inducing the aggregation of ergosterol and restructuring of the fungal plasma membrane.

Original language	English
Pages (from-to)	822-825
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	5
DOIs	https://doi.org/10.1039/c9cc08908j
Publication status	Published - 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 The Royal Society of Chemistry.

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c9cc08908j

Cite this

@article{552679d675bf4f079bd5e755e054f2a2,

title = "Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin",

abstract = "Produced by a newly isolated Streptomycetes strain, meijiemycin is a gigantic linear polyene-polyol that exhibits structural features not seen in other members of the polyene-polyol family. We propose a biosynthetic mechanism and demonstrate that meijiemycin inhibits hyphal growth by inducing the aggregation of ergosterol and restructuring of the fungal plasma membrane.",

author = "Low, {Zhen Jie} and Juan Xiong and Ying Xie and Ma, {Guang Lei} and Howard Saw and {Thi Tran}, Hoa and Wong, {Soo Lin} and Pang, {Li Mei} and July Fong and Peng Lu and Hu, {Jin Feng} and Yang Liang and Yansong Miao and Liang, {Zhao Xun}",

note = "Publisher Copyright: {\textcopyright} 2020 The Royal Society of Chemistry.",

year = "2020",

doi = "10.1039/c9cc08908j",

language = "English",

volume = "56",

pages = "822--825",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "5",

}

TY - JOUR

T1 - Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin

AU - Low, Zhen Jie

AU - Xiong, Juan

AU - Xie, Ying

AU - Ma, Guang Lei

AU - Saw, Howard

AU - Thi Tran, Hoa

AU - Wong, Soo Lin

AU - Pang, Li Mei

AU - Fong, July

AU - Lu, Peng

AU - Hu, Jin Feng

AU - Liang, Yang

AU - Miao, Yansong

AU - Liang, Zhao Xun

PY - 2020

Y1 - 2020

N2 - Produced by a newly isolated Streptomycetes strain, meijiemycin is a gigantic linear polyene-polyol that exhibits structural features not seen in other members of the polyene-polyol family. We propose a biosynthetic mechanism and demonstrate that meijiemycin inhibits hyphal growth by inducing the aggregation of ergosterol and restructuring of the fungal plasma membrane.

AB - Produced by a newly isolated Streptomycetes strain, meijiemycin is a gigantic linear polyene-polyol that exhibits structural features not seen in other members of the polyene-polyol family. We propose a biosynthetic mechanism and demonstrate that meijiemycin inhibits hyphal growth by inducing the aggregation of ergosterol and restructuring of the fungal plasma membrane.

UR - http://www.scopus.com/inward/record.url?scp=85077944927&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85077944927&partnerID=8YFLogxK

U2 - 10.1039/c9cc08908j

DO - 10.1039/c9cc08908j

M3 - Article

C2 - 31848534

AN - SCOPUS:85077944927

SN - 1359-7345

VL - 56

SP - 822

EP - 825

JO - Chemical Communications

JF - Chemical Communications

IS - 5

ER -

Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Access to Document

Other files and links

Fingerprint

Cite this