DNA-functionalized thermoresponsive bioconjugates synthesized via ATRP and click chemistry

Pengju Pan; Masahiro Fujita; Wei Yang Ooi; Kumar Sudesh; Tohru Takarada; Atsushi Goto; Mizuo Maeda

doi:10.1016/j.polymer.2011.01.016

DNA-functionalized thermoresponsive bioconjugates synthesized via ATRP and click chemistry

Pengju Pan, Masahiro Fujita^*, Wei Yang Ooi, Kumar Sudesh, Tohru Takarada, Atsushi Goto, Mizuo Maeda

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Diblock and miktoarm star-shaped thermoresponsive copolymers composed of single-stranded DNA (ssDNA) and poly(N-isopropylacrylamide) were successfully synthesized with combination of atom transfer radical polymerization (ATRP) and click chemistry. This approach should be generalizable to other DNA-functionalized copolymers. Such copolymers self-assemble into spherical micelles with ssDNA corona in aqueous solution above the lower critical solution temperature. The micellar size can be tuned from the macromolecular architecture. These DNA-encoded micellar particles are able to encapsulate and release hydrophobic guest molecules upon changing temperature.

Original language	English
Pages (from-to)	895-900
Number of pages	6
Journal	Polymer
Volume	52
Issue number	4
DOIs	https://doi.org/10.1016/j.polymer.2011.01.016
Publication status	Published - Feb 17 2011
Externally published	Yes

ASJC Scopus Subject Areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

Keywords

ATRP
Click chemistry
DNA

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10.1016/j.polymer.2011.01.016

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title = "DNA-functionalized thermoresponsive bioconjugates synthesized via ATRP and click chemistry",

abstract = "Diblock and miktoarm star-shaped thermoresponsive copolymers composed of single-stranded DNA (ssDNA) and poly(N-isopropylacrylamide) were successfully synthesized with combination of atom transfer radical polymerization (ATRP) and click chemistry. This approach should be generalizable to other DNA-functionalized copolymers. Such copolymers self-assemble into spherical micelles with ssDNA corona in aqueous solution above the lower critical solution temperature. The micellar size can be tuned from the macromolecular architecture. These DNA-encoded micellar particles are able to encapsulate and release hydrophobic guest molecules upon changing temperature.",

keywords = "ATRP, Click chemistry, DNA",

author = "Pengju Pan and Masahiro Fujita and Ooi, {Wei Yang} and Kumar Sudesh and Tohru Takarada and Atsushi Goto and Mizuo Maeda",

year = "2011",

month = feb,

day = "17",

doi = "10.1016/j.polymer.2011.01.016",

language = "English",

volume = "52",

pages = "895--900",

journal = "Polymer",

issn = "0032-3861",

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TY - JOUR

T1 - DNA-functionalized thermoresponsive bioconjugates synthesized via ATRP and click chemistry

AU - Pan, Pengju

AU - Fujita, Masahiro

AU - Ooi, Wei Yang

AU - Sudesh, Kumar

AU - Takarada, Tohru

AU - Goto, Atsushi

AU - Maeda, Mizuo

PY - 2011/2/17

Y1 - 2011/2/17

N2 - Diblock and miktoarm star-shaped thermoresponsive copolymers composed of single-stranded DNA (ssDNA) and poly(N-isopropylacrylamide) were successfully synthesized with combination of atom transfer radical polymerization (ATRP) and click chemistry. This approach should be generalizable to other DNA-functionalized copolymers. Such copolymers self-assemble into spherical micelles with ssDNA corona in aqueous solution above the lower critical solution temperature. The micellar size can be tuned from the macromolecular architecture. These DNA-encoded micellar particles are able to encapsulate and release hydrophobic guest molecules upon changing temperature.

AB - Diblock and miktoarm star-shaped thermoresponsive copolymers composed of single-stranded DNA (ssDNA) and poly(N-isopropylacrylamide) were successfully synthesized with combination of atom transfer radical polymerization (ATRP) and click chemistry. This approach should be generalizable to other DNA-functionalized copolymers. Such copolymers self-assemble into spherical micelles with ssDNA corona in aqueous solution above the lower critical solution temperature. The micellar size can be tuned from the macromolecular architecture. These DNA-encoded micellar particles are able to encapsulate and release hydrophobic guest molecules upon changing temperature.

KW - ATRP

KW - Click chemistry

KW - DNA

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U2 - 10.1016/j.polymer.2011.01.016

DO - 10.1016/j.polymer.2011.01.016

M3 - Article

AN - SCOPUS:79751538421

SN - 0032-3861

VL - 52

SP - 895

EP - 900

JO - Polymer

JF - Polymer

IS - 4

ER -

DNA-functionalized thermoresponsive bioconjugates synthesized via ATRP and click chemistry

Abstract

ASJC Scopus Subject Areas

Keywords

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