Doxorubicin and paclitaxel carried by methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) is superior than traditional drug-delivery methods

Yili Hu; Xiaoyang Zhu; Ruifang Zhao; Jin Wang; Yipeng Song; Guangjun Nie; Huiru Tang; Yulan Wang

doi:10.2217/nnm-2017-0363

Doxorubicin and paclitaxel carried by methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) is superior than traditional drug-delivery methods

Yili Hu, Xiaoyang Zhu, Ruifang Zhao, Jin Wang, Yipeng Song, Guangjun Nie, Huiru Tang, Yulan Wang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Aim: To evaluate the advantages of nanomaterial methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) (mPEG-PLGA) encapsulated doxorubicin (D/DOX) and paclitaxel (T/TAX; mPEG-PLGA-DT) over free form of DOX and TAX (DOX/TAX). Materials & methods: Metabonomics was conducted to characterize the systemic metabolic response of allograft breast cancer model mice to mPEG-PLGA-DT and DOX/TAX treatments. Results: Breast tumor growth induced metabolic reprogram in serum and multiple organs. DOX/TAX treatment could ameliorate the elevated energy and nucleotides demands in some organs while mPEG-PLGA-DT treatment showed outstanding therapeutic outcomes in restoring the metabolic phenotypes of serum and kidney from tumor-bearing mice to the healthy state. Conclusion: This investigation proved the biological advantages of mPEG-PLGA-DT over DOX/TAX in molecular level through the comparison between their metabolic responses in vivo.

Original language	English
Pages (from-to)	913-928
Number of pages	16
Journal	Nanomedicine
Volume	13
Issue number	8
DOIs	https://doi.org/10.2217/nnm-2017-0363
Publication status	Published - Apr 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 Future Medicine Ltd.

ASJC Scopus Subject Areas

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
General Materials Science
Development

Keywords

Anticancer drugs
Biomedical applications
Metabonomics
NMR
Nuclear magnetic resonance
Polymer nanoparticles

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/nnm-2017-0363

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title = "Doxorubicin and paclitaxel carried by methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) is superior than traditional drug-delivery methods",

abstract = "Aim: To evaluate the advantages of nanomaterial methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) (mPEG-PLGA) encapsulated doxorubicin (D/DOX) and paclitaxel (T/TAX; mPEG-PLGA-DT) over free form of DOX and TAX (DOX/TAX). Materials & methods: Metabonomics was conducted to characterize the systemic metabolic response of allograft breast cancer model mice to mPEG-PLGA-DT and DOX/TAX treatments. Results: Breast tumor growth induced metabolic reprogram in serum and multiple organs. DOX/TAX treatment could ameliorate the elevated energy and nucleotides demands in some organs while mPEG-PLGA-DT treatment showed outstanding therapeutic outcomes in restoring the metabolic phenotypes of serum and kidney from tumor-bearing mice to the healthy state. Conclusion: This investigation proved the biological advantages of mPEG-PLGA-DT over DOX/TAX in molecular level through the comparison between their metabolic responses in vivo.",

keywords = "Anticancer drugs, Biomedical applications, Metabonomics, NMR, Nuclear magnetic resonance, Polymer nanoparticles",

author = "Yili Hu and Xiaoyang Zhu and Ruifang Zhao and Jin Wang and Yipeng Song and Guangjun Nie and Huiru Tang and Yulan Wang",

note = "Publisher Copyright: {\textcopyright} 2018 Future Medicine Ltd.",

year = "2018",

month = apr,

doi = "10.2217/nnm-2017-0363",

language = "English",

volume = "13",

pages = "913--928",

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AU - Hu, Yili

AU - Zhu, Xiaoyang

AU - Zhao, Ruifang

AU - Wang, Jin

AU - Song, Yipeng

AU - Nie, Guangjun

AU - Tang, Huiru

AU - Wang, Yulan

PY - 2018/4

Y1 - 2018/4

N2 - Aim: To evaluate the advantages of nanomaterial methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) (mPEG-PLGA) encapsulated doxorubicin (D/DOX) and paclitaxel (T/TAX; mPEG-PLGA-DT) over free form of DOX and TAX (DOX/TAX). Materials & methods: Metabonomics was conducted to characterize the systemic metabolic response of allograft breast cancer model mice to mPEG-PLGA-DT and DOX/TAX treatments. Results: Breast tumor growth induced metabolic reprogram in serum and multiple organs. DOX/TAX treatment could ameliorate the elevated energy and nucleotides demands in some organs while mPEG-PLGA-DT treatment showed outstanding therapeutic outcomes in restoring the metabolic phenotypes of serum and kidney from tumor-bearing mice to the healthy state. Conclusion: This investigation proved the biological advantages of mPEG-PLGA-DT over DOX/TAX in molecular level through the comparison between their metabolic responses in vivo.

AB - Aim: To evaluate the advantages of nanomaterial methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) (mPEG-PLGA) encapsulated doxorubicin (D/DOX) and paclitaxel (T/TAX; mPEG-PLGA-DT) over free form of DOX and TAX (DOX/TAX). Materials & methods: Metabonomics was conducted to characterize the systemic metabolic response of allograft breast cancer model mice to mPEG-PLGA-DT and DOX/TAX treatments. Results: Breast tumor growth induced metabolic reprogram in serum and multiple organs. DOX/TAX treatment could ameliorate the elevated energy and nucleotides demands in some organs while mPEG-PLGA-DT treatment showed outstanding therapeutic outcomes in restoring the metabolic phenotypes of serum and kidney from tumor-bearing mice to the healthy state. Conclusion: This investigation proved the biological advantages of mPEG-PLGA-DT over DOX/TAX in molecular level through the comparison between their metabolic responses in vivo.

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KW - NMR

KW - Nuclear magnetic resonance

KW - Polymer nanoparticles

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Doxorubicin and paclitaxel carried by methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) is superior than traditional drug-delivery methods

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

UN SDGs

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