Drugging Hedgehog: Signaling the pathway to translation

Tom J. Carney; Philip W. Ingham

doi:10.1186/1741-7007-11-37

Drugging Hedgehog: Signaling the pathway to translation

Tom J. Carney, Philip W. Ingham^*

^*Corresponding author for this work

Agency for Science, Technology and Research, Singapore

Research output: Contribution to journal › Review article › peer-review

16 Citations (Scopus)

Abstract

First discovered in Drosophila, the Hedgehog signaling pathway controls a wide range of developmental processes and is implicated in a variety of cancers. The success of a screen for chemical modulators of this pathway, published in 2002, opened a new chapter in the quest to translate the results of basic developmental biology research into therapeutic applications. Small molecule pathway agonists are now used to program stem cells, whilst antagonists are proving effective as anti-cancer therapies.

Original language	English
Article number	37
Journal	BMC Biology
Volume	11
DOIs	https://doi.org/10.1186/1741-7007-11-37
Publication status	Published - Apr 15 2013
Externally published	Yes

ASJC Scopus Subject Areas

Biotechnology
Structural Biology
Ecology, Evolution, Behavior and Systematics
Physiology
General Biochemistry,Genetics and Molecular Biology
General Agricultural and Biological Sciences
Plant Science
Developmental Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/1741-7007-11-37

Cite this

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AB - First discovered in Drosophila, the Hedgehog signaling pathway controls a wide range of developmental processes and is implicated in a variety of cancers. The success of a screen for chemical modulators of this pathway, published in 2002, opened a new chapter in the quest to translate the results of basic developmental biology research into therapeutic applications. Small molecule pathway agonists are now used to program stem cells, whilst antagonists are proving effective as anti-cancer therapies.

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Drugging Hedgehog: Signaling the pathway to translation

Abstract

ASJC Scopus Subject Areas

UN SDGs

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