TY - JOUR
T1 - Effects of 16S rRNA gene mutations on tetracycline resistance in Helicobacter pylori
AU - Gerrits, Monique M.
AU - Berning, Marco
AU - Van Vliet, Arnoud H.M.
AU - Kuipers, Ernst J.
AU - Kusters, Johannes G.
PY - 2003/9/1
Y1 - 2003/9/1
N2 - The triple-base-pair 16S rDNA mutation AGA926-928→TTC mediates high-level tetracycline resistance in Helicobacter pylori. In contrast, single- and double-base-pair mutations mediated only low-level tetracycline resistance and decreased growth rates in the presence of tetracycline, explaining the preference for the TTC mutation in tetracycline-resistant H. pylori isolates.
AB - The triple-base-pair 16S rDNA mutation AGA926-928→TTC mediates high-level tetracycline resistance in Helicobacter pylori. In contrast, single- and double-base-pair mutations mediated only low-level tetracycline resistance and decreased growth rates in the presence of tetracycline, explaining the preference for the TTC mutation in tetracycline-resistant H. pylori isolates.
UR - http://www.scopus.com/inward/record.url?scp=0042924338&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0042924338&partnerID=8YFLogxK
U2 - 10.1128/AAC.47.9.2984-2986.2003
DO - 10.1128/AAC.47.9.2984-2986.2003
M3 - Article
C2 - 12937008
AN - SCOPUS:0042924338
SN - 0066-4804
VL - 47
SP - 2984
EP - 2986
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 9
ER -
