Efficient and controllable synthesis of highly substituted gelatin methacrylamide for mechanically stiff hydrogels

Bae Hoon Lee; Hitomi Shirahama; Nam Joon Cho; Lay Poh Tan

doi:10.1039/c5ra22028a

Efficient and controllable synthesis of highly substituted gelatin methacrylamide for mechanically stiff hydrogels

Bae Hoon Lee, Hitomi Shirahama, Nam Joon Cho^*, Lay Poh Tan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

140 Citations (Scopus)

Abstract

We report an effective and novel method to controllably produce highly substituted gelatin-MA with nearly 100% degree of substitution despite the use of a very low concentration of methacrylic anhydride (MAA). The method is based on sequential time-lapse loading of MAA after pH adjustment in a carbonate-bicarbonate buffer system. Rheological studies indicate that hydrogels formed from more highly substituted gelatin-MA exhibit significantly improved mechanical stiffness.

Original language	English
Pages (from-to)	106094-106097
Number of pages	4
Journal	RSC Advances
Volume	5
Issue number	128
DOIs	https://doi.org/10.1039/c5ra22028a
Publication status	Published - 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry.

ASJC Scopus Subject Areas

General Chemistry
General Chemical Engineering

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10.1039/c5ra22028a

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abstract = "We report an effective and novel method to controllably produce highly substituted gelatin-MA with nearly 100% degree of substitution despite the use of a very low concentration of methacrylic anhydride (MAA). The method is based on sequential time-lapse loading of MAA after pH adjustment in a carbonate-bicarbonate buffer system. Rheological studies indicate that hydrogels formed from more highly substituted gelatin-MA exhibit significantly improved mechanical stiffness.",

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AU - Shirahama, Hitomi

AU - Cho, Nam Joon

AU - Tan, Lay Poh

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Y1 - 2015

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AB - We report an effective and novel method to controllably produce highly substituted gelatin-MA with nearly 100% degree of substitution despite the use of a very low concentration of methacrylic anhydride (MAA). The method is based on sequential time-lapse loading of MAA after pH adjustment in a carbonate-bicarbonate buffer system. Rheological studies indicate that hydrogels formed from more highly substituted gelatin-MA exhibit significantly improved mechanical stiffness.

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Efficient and controllable synthesis of highly substituted gelatin methacrylamide for mechanically stiff hydrogels

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Access to Document

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