Abstract
Targeted delivery of therapeutic agents to malignant tissues is crucial for enhancing clinical outcomes and reducing side effects. Magnetic nanorobots (MNRs) present a promising strategy for controlled delivery, leveraging external magnetic fields to achieve precise in vivo targeting. This work develops elongated MNRs comprising linearly arranged magnetic nanoparticles linked by metal-polyphenol complexes (MPCs) for magnetic-field-directed active tumor targeting and synergistic tumor therapy. The MNRs are created by assembling 30 nm Fe3O4 nanoparticles, tannic acid, and ferrous ions (Fe2+) under a uniform magnetic field, resulting in elongated chain-like structures fixed by MPCs, which also promotes peroxidase-like activity. These structures show a greater magnetic response than individual nanoparticles, offering flexibility in magnetic manipulation. The MPCs coating allows tailored surface modifications with glucose oxidase, copper ions (Cu2+), and human serum albumin (HSA), producing colloidally stable MNRs with a built-in multienzymatic cascade (MNRs@GOx/Cu/HSA) that consumes glucose, generates •OH, and depletes the antioxidant glutathione (GSH). Collectively, surface-engineered multifunctional MNRs demonstrate improved in vivo tumor targeting driven by external magnetic fields, leading to efficient localized chemodynamic therapy. The tailored structural and functional properties of the developed MNRs render them suitable for targeted cargo delivery, minimally invasive surgery, and localized treatments in disease sites.
Original language | English |
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Pages (from-to) | 15040-15054 |
Number of pages | 15 |
Journal | ACS Nano |
Volume | 19 |
Issue number | 15 |
DOIs | |
Publication status | Published - Apr 22 2025 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2025 American Chemical Society.
ASJC Scopus Subject Areas
- General Materials Science
- General Engineering
- General Physics and Astronomy
Keywords
- active targeting
- cancer therapy
- magnetic nanorobots
- metal-polyphenol complexes
- muti-enzymatic catalysis