Embedding a Ruthenium-Based Structural Mimic of the [Fe]-Hydrogenase Cofactor into Papain

Chandan Kr Barik; Rakesh Ganguly; Yongxin Li; Cédric Przybylski; Michèle Salmain; Weng Kee Leong

doi:10.1021/acs.inorgchem.8b01835

Embedding a Ruthenium-Based Structural Mimic of the [Fe]-Hydrogenase Cofactor into Papain

Chandan Kr Barik, Rakesh Ganguly, Yongxin Li, Cédric Przybylski, Michèle Salmain^*, Weng Kee Leong

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

We describe the synthesis of the ruthenacyclic carbamoyl complexes [Ru(2-NHC(O)C₅H₃NMe)(CO)₂(o,o-Me₂-C₆H₃S)(L)] (L = H₂O or MeCN), which have a labile water or acetonitrile ligand at their sixth coordination sites. Steric bulk around the ruthenium center is essential in preventing isomerization and dimerization, and embedding within papain can be achieved via coordination of its sole free cysteine residue. The observed chemistry parallels that of the natural [Fe]-hydrogenase.

Original language	English
Pages (from-to)	12206-12212
Number of pages	7
Journal	Inorganic Chemistry
Volume	57
Issue number	19
DOIs	https://doi.org/10.1021/acs.inorgchem.8b01835
Publication status	Published - Oct 1 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
Copyright © 2018 American Chemical Society.

ASJC Scopus Subject Areas

Physical and Theoretical Chemistry
Inorganic Chemistry

Access to Document

10.1021/acs.inorgchem.8b01835

Cite this

@article{52b741bfc40f42c288ac1fe14a1cc3cc,

title = "Embedding a Ruthenium-Based Structural Mimic of the [Fe]-Hydrogenase Cofactor into Papain",

abstract = "We describe the synthesis of the ruthenacyclic carbamoyl complexes [Ru(2-NHC(O)C5H3NMe)(CO)2(o,o-Me2-C6H3S)(L)] (L = H2O or MeCN), which have a labile water or acetonitrile ligand at their sixth coordination sites. Steric bulk around the ruthenium center is essential in preventing isomerization and dimerization, and embedding within papain can be achieved via coordination of its sole free cysteine residue. The observed chemistry parallels that of the natural [Fe]-hydrogenase.",

author = "Barik, {Chandan Kr} and Rakesh Ganguly and Yongxin Li and C{\'e}dric Przybylski and Mich{\`e}le Salmain and Leong, {Weng Kee}",

note = "Publisher Copyright: Copyright {\textcopyright} 2018 American Chemical Society.",

year = "2018",

month = oct,

day = "1",

doi = "10.1021/acs.inorgchem.8b01835",

language = "English",

volume = "57",

pages = "12206--12212",

journal = "Inorganic Chemistry",

issn = "0020-1669",

publisher = "American Chemical Society",

number = "19",

}

TY - JOUR

T1 - Embedding a Ruthenium-Based Structural Mimic of the [Fe]-Hydrogenase Cofactor into Papain

AU - Barik, Chandan Kr

AU - Ganguly, Rakesh

AU - Li, Yongxin

AU - Przybylski, Cédric

AU - Salmain, Michèle

AU - Leong, Weng Kee

PY - 2018/10/1

Y1 - 2018/10/1

N2 - We describe the synthesis of the ruthenacyclic carbamoyl complexes [Ru(2-NHC(O)C5H3NMe)(CO)2(o,o-Me2-C6H3S)(L)] (L = H2O or MeCN), which have a labile water or acetonitrile ligand at their sixth coordination sites. Steric bulk around the ruthenium center is essential in preventing isomerization and dimerization, and embedding within papain can be achieved via coordination of its sole free cysteine residue. The observed chemistry parallels that of the natural [Fe]-hydrogenase.

AB - We describe the synthesis of the ruthenacyclic carbamoyl complexes [Ru(2-NHC(O)C5H3NMe)(CO)2(o,o-Me2-C6H3S)(L)] (L = H2O or MeCN), which have a labile water or acetonitrile ligand at their sixth coordination sites. Steric bulk around the ruthenium center is essential in preventing isomerization and dimerization, and embedding within papain can be achieved via coordination of its sole free cysteine residue. The observed chemistry parallels that of the natural [Fe]-hydrogenase.

UR - http://www.scopus.com/inward/record.url?scp=85053309917&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053309917&partnerID=8YFLogxK

U2 - 10.1021/acs.inorgchem.8b01835

DO - 10.1021/acs.inorgchem.8b01835

M3 - Article

C2 - 30198260

AN - SCOPUS:85053309917

SN - 0020-1669

VL - 57

SP - 12206

EP - 12212

JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 19

ER -

Embedding a Ruthenium-Based Structural Mimic of the [Fe]-Hydrogenase Cofactor into Papain

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Access to Document

Other files and links

Fingerprint

Cite this