Enhancing the toxicity of cancer chemotherapeutics with gold nanorod hyperthermia

Tanya S. Hauck; Travis L. Jennings; Tetyana Yatsenko; J. Carl Kumaradas; Warren C.W. Chan

doi:10.1002/adma.200800921

Enhancing the toxicity of cancer chemotherapeutics with gold nanorod hyperthermia

Tanya S. Hauck, Travis L. Jennings, Tetyana Yatsenko, J. Carl Kumaradas, Warren C.W. Chan

Research output: Contribution to journal › Article › peer-review

367 Citations (Scopus)

Abstract

The use of heat producing GNRs to augment the dosing of chemotherapeutic agents in cultured mammalian cells was investigated. Hexadecyltrimethylammonium bromide was purchased from Fluka. GNRs were synthesized using standard protocols detailed in a previous publication, with reference to the Murphy and Liz-Marzán groups. GNRs were synthesized by combining CTAB, gold chloride, silver nitrate, ascorbic acid, and gold seed. GNRs were coated in Poly(diallyldimethylammonium chloride) (PDADMAC) by washing as-synthesized material twice in distilled water resuspending in 1 mM NaCl, and coated with a layer of negatively charged PSS followed by a layer of positively charged PDADMAC. It was observed that nanoparticles offer localized heating with a non-invasive probe, and provide heat generation inside cancerous cells.

Original language	English
Pages (from-to)	3832-3838
Number of pages	7
Journal	Advanced Materials
Volume	20
Issue number	20
DOIs	https://doi.org/10.1002/adma.200800921
Publication status	Published - Oct 17 2008
Externally published	Yes

ASJC Scopus Subject Areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/adma.200800921

Cite this

@article{d8f3e19681f041ba969eebf0d3c39351,

title = "Enhancing the toxicity of cancer chemotherapeutics with gold nanorod hyperthermia",

abstract = "The use of heat producing GNRs to augment the dosing of chemotherapeutic agents in cultured mammalian cells was investigated. Hexadecyltrimethylammonium bromide was purchased from Fluka. GNRs were synthesized using standard protocols detailed in a previous publication, with reference to the Murphy and Liz-Marz{\'a}n groups. GNRs were synthesized by combining CTAB, gold chloride, silver nitrate, ascorbic acid, and gold seed. GNRs were coated in Poly(diallyldimethylammonium chloride) (PDADMAC) by washing as-synthesized material twice in distilled water resuspending in 1 mM NaCl, and coated with a layer of negatively charged PSS followed by a layer of positively charged PDADMAC. It was observed that nanoparticles offer localized heating with a non-invasive probe, and provide heat generation inside cancerous cells.",

author = "Hauck, {Tanya S.} and Jennings, {Travis L.} and Tetyana Yatsenko and Kumaradas, {J. Carl} and Chan, {Warren C.W.}",

year = "2008",

month = oct,

day = "17",

doi = "10.1002/adma.200800921",

language = "English",

volume = "20",

pages = "3832--3838",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-VCH Verlag",

number = "20",

}

TY - JOUR

T1 - Enhancing the toxicity of cancer chemotherapeutics with gold nanorod hyperthermia

AU - Hauck, Tanya S.

AU - Jennings, Travis L.

AU - Yatsenko, Tetyana

AU - Kumaradas, J. Carl

AU - Chan, Warren C.W.

PY - 2008/10/17

Y1 - 2008/10/17

N2 - The use of heat producing GNRs to augment the dosing of chemotherapeutic agents in cultured mammalian cells was investigated. Hexadecyltrimethylammonium bromide was purchased from Fluka. GNRs were synthesized using standard protocols detailed in a previous publication, with reference to the Murphy and Liz-Marzán groups. GNRs were synthesized by combining CTAB, gold chloride, silver nitrate, ascorbic acid, and gold seed. GNRs were coated in Poly(diallyldimethylammonium chloride) (PDADMAC) by washing as-synthesized material twice in distilled water resuspending in 1 mM NaCl, and coated with a layer of negatively charged PSS followed by a layer of positively charged PDADMAC. It was observed that nanoparticles offer localized heating with a non-invasive probe, and provide heat generation inside cancerous cells.

AB - The use of heat producing GNRs to augment the dosing of chemotherapeutic agents in cultured mammalian cells was investigated. Hexadecyltrimethylammonium bromide was purchased from Fluka. GNRs were synthesized using standard protocols detailed in a previous publication, with reference to the Murphy and Liz-Marzán groups. GNRs were synthesized by combining CTAB, gold chloride, silver nitrate, ascorbic acid, and gold seed. GNRs were coated in Poly(diallyldimethylammonium chloride) (PDADMAC) by washing as-synthesized material twice in distilled water resuspending in 1 mM NaCl, and coated with a layer of negatively charged PSS followed by a layer of positively charged PDADMAC. It was observed that nanoparticles offer localized heating with a non-invasive probe, and provide heat generation inside cancerous cells.

UR - http://www.scopus.com/inward/record.url?scp=55749107832&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55749107832&partnerID=8YFLogxK

U2 - 10.1002/adma.200800921

DO - 10.1002/adma.200800921

M3 - Article

AN - SCOPUS:55749107832

SN - 0935-9648

VL - 20

SP - 3832

EP - 3838

JO - Advanced Materials

JF - Advanced Materials

IS - 20

ER -

Enhancing the toxicity of cancer chemotherapeutics with gold nanorod hyperthermia

Abstract

ASJC Scopus Subject Areas

UN SDGs

Access to Document

Other files and links

Cite this