European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

Weang Kee Ho; Min Min Tan; Nasim Mavaddat; Mei Chee Tai; Shivaani Mariapun; Jingmei Li; Peh Joo Ho; Joe Dennis; Jonathan P. Tyrer; Manjeet K. Bolla; Kyriaki Michailidou; Qin Wang; Daehee Kang; Ji Yeob Choi; Suniza Jamaris; Xiao Ou Shu; Sook Yee Yoon; Sue K. Park; Sung Won Kim; Chen Yang Shen; Jyh Cherng Yu; Ern Yu Tan; Patrick Mun Yew Chan; Kenneth Muir; Artitaya Lophatananon; Anna H. Wu; Daniel O. Stram; Keitaro Matsuo; Hidemi Ito; Ching Wan Chan; Joanne Ngeow; Wei Sean Yong; Swee Ho Lim; Geok Hoon Lim; Ava Kwong; Tsun L. Chan; Su Ming Tan; Jaime Seah; Esther M. John; Allison W. Kurian; Woon Puay Koh; Chiea Chuen Khor; Motoki Iwasaki; Taiki Yamaji; Kiak Mien Veronique Tan; Kiat Tee Benita Tan; John J. Spinelli; Kristan J. Aronson; Siti Norhidayu Hasan; Kartini Rahmat; Anushya Vijayananthan; Xueling Sim; Paul D.P. Pharoah; Wei Zheng; Alison M. Dunning; Jacques Simard; Rob Martinus van Dam; Cheng Har Yip; Nur Aishah Mohd Taib; Mikael Hartman; Douglas F. Easton; Soo Hwang Teo; Antonis C. Antoniou

doi:10.1038/s41467-020-17680-w

European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

Weang Kee Ho^*, Min Min Tan, Nasim Mavaddat, Mei Chee Tai, Shivaani Mariapun, Jingmei Li, Peh Joo Ho, Joe Dennis, Jonathan P. Tyrer, Manjeet K. Bolla, Kyriaki Michailidou, Qin Wang, Daehee Kang, Ji Yeob Choi, Suniza Jamaris, Xiao Ou Shu, Sook Yee Yoon, Sue K. Park, Sung Won Kim, Chen Yang ShenJyh Cherng Yu, Ern Yu Tan, Patrick Mun Yew Chan, Kenneth Muir, Artitaya Lophatananon, Anna H. Wu, Daniel O. Stram, Keitaro Matsuo, Hidemi Ito, Ching Wan Chan, Joanne Ngeow, Wei Sean Yong, Swee Ho Lim, Geok Hoon Lim, Ava Kwong, Tsun L. Chan, Su Ming Tan, Jaime Seah, Esther M. John, Allison W. Kurian, Woon Puay Koh, Chiea Chuen Khor, Motoki Iwasaki, Taiki Yamaji, Kiak Mien Veronique Tan, Kiat Tee Benita Tan, John J. Spinelli, Kristan J. Aronson, Siti Norhidayu Hasan, Kartini Rahmat, Anushya Vijayananthan, Xueling Sim, Paul D.P. Pharoah, Wei Zheng, Alison M. Dunning, Jacques Simard, Rob Martinus van Dam, Cheng Har Yip, Nur Aishah Mohd Taib, Mikael Hartman, Douglas F. Easton, Soo Hwang Teo^*, Antonis C. Antoniou

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to women in the middle quintile of the risk distribution, women in the highest 1% of PRS distribution have a ~2.7-fold risk and women in the lowest 1% of PRS distribution has ~0.4-fold risk of developing breast cancer. There is no evidence of heterogeneity in PRS performance in Chinese, Malay and Indian women. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia.

Original language	English
Article number	3833
Journal	Nature Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-17680-w
Publication status	Published - Dec 1 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020, The Author(s).

ASJC Scopus Subject Areas

General Chemistry
General Biochemistry,Genetics and Molecular Biology
General Physics and Astronomy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41467-020-17680-w

Cite this

Ho, W. K., Tan, M. M., Mavaddat, N., Tai, M. C., Mariapun, S., Li, J., Ho, P. J., Dennis, J., Tyrer, J. P., Bolla, M. K., Michailidou, K., Wang, Q., Kang, D., Choi, J. Y., Jamaris, S., Shu, X. O., Yoon, S. Y., Park, S. K., Kim, S. W., ... Antoniou, A. C. (2020). European polygenic risk score for prediction of breast cancer shows similar performance in Asian women. Nature Communications, 11(1), Article 3833. https://doi.org/10.1038/s41467-020-17680-w

@article{71357be9a6084c0fbbb1bc970521022f,

title = "European polygenic risk score for prediction of breast cancer shows similar performance in Asian women",

abstract = "Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to women in the middle quintile of the risk distribution, women in the highest 1% of PRS distribution have a ~2.7-fold risk and women in the lowest 1% of PRS distribution has ~0.4-fold risk of developing breast cancer. There is no evidence of heterogeneity in PRS performance in Chinese, Malay and Indian women. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia.",

author = "Ho, {Weang Kee} and Tan, {Min Min} and Nasim Mavaddat and Tai, {Mei Chee} and Shivaani Mariapun and Jingmei Li and Ho, {Peh Joo} and Joe Dennis and Tyrer, {Jonathan P.} and Bolla, {Manjeet K.} and Kyriaki Michailidou and Qin Wang and Daehee Kang and Choi, {Ji Yeob} and Suniza Jamaris and Shu, {Xiao Ou} and Yoon, {Sook Yee} and Park, {Sue K.} and Kim, {Sung Won} and Shen, {Chen Yang} and Yu, {Jyh Cherng} and Tan, {Ern Yu} and Chan, {Patrick Mun Yew} and Kenneth Muir and Artitaya Lophatananon and Wu, {Anna H.} and Stram, {Daniel O.} and Keitaro Matsuo and Hidemi Ito and Chan, {Ching Wan} and Joanne Ngeow and Yong, {Wei Sean} and Lim, {Swee Ho} and Lim, {Geok Hoon} and Ava Kwong and Chan, {Tsun L.} and Tan, {Su Ming} and Jaime Seah and John, {Esther M.} and Kurian, {Allison W.} and Koh, {Woon Puay} and Khor, {Chiea Chuen} and Motoki Iwasaki and Taiki Yamaji and Tan, {Kiak Mien Veronique} and Tan, {Kiat Tee Benita} and Spinelli, {John J.} and Aronson, {Kristan J.} and Hasan, {Siti Norhidayu} and Kartini Rahmat and Anushya Vijayananthan and Xueling Sim and Pharoah, {Paul D.P.} and Wei Zheng and Dunning, {Alison M.} and Jacques Simard and {van Dam}, {Rob Martinus} and Yip, {Cheng Har} and Taib, {Nur Aishah Mohd} and Mikael Hartman and Easton, {Douglas F.} and Teo, {Soo Hwang} and Antoniou, {Antonis C.}",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2020",

month = dec,

day = "1",

doi = "10.1038/s41467-020-17680-w",

language = "English",

volume = "11",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

number = "1",

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Ho, WK, Tan, MM, Mavaddat, N, Tai, MC, Mariapun, S, Li, J, Ho, PJ, Dennis, J, Tyrer, JP, Bolla, MK, Michailidou, K, Wang, Q, Kang, D, Choi, JY, Jamaris, S, Shu, XO, Yoon, SY, Park, SK, Kim, SW, Shen, CY, Yu, JC, Tan, EY, Chan, PMY, Muir, K, Lophatananon, A, Wu, AH, Stram, DO, Matsuo, K, Ito, H, Chan, CW, Ngeow, J, Yong, WS, Lim, SH, Lim, GH, Kwong, A, Chan, TL, Tan, SM, Seah, J, John, EM, Kurian, AW, Koh, WP, Khor, CC, Iwasaki, M, Yamaji, T, Tan, KMV, Tan, KTB, Spinelli, JJ, Aronson, KJ, Hasan, SN, Rahmat, K, Vijayananthan, A, Sim, X, Pharoah, PDP, Zheng, W, Dunning, AM, Simard, J, van Dam, RM, Yip, CH, Taib, NAM, Hartman, M, Easton, DF, Teo, SH & Antoniou, AC 2020, 'European polygenic risk score for prediction of breast cancer shows similar performance in Asian women', Nature Communications, vol. 11, no. 1, 3833. https://doi.org/10.1038/s41467-020-17680-w

TY - JOUR

T1 - European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

AU - Ho, Weang Kee

AU - Tan, Min Min

AU - Mavaddat, Nasim

AU - Tai, Mei Chee

AU - Mariapun, Shivaani

AU - Li, Jingmei

AU - Ho, Peh Joo

AU - Dennis, Joe

AU - Tyrer, Jonathan P.

AU - Bolla, Manjeet K.

AU - Michailidou, Kyriaki

AU - Wang, Qin

AU - Kang, Daehee

AU - Choi, Ji Yeob

AU - Jamaris, Suniza

AU - Shu, Xiao Ou

AU - Yoon, Sook Yee

AU - Park, Sue K.

AU - Kim, Sung Won

AU - Shen, Chen Yang

AU - Yu, Jyh Cherng

AU - Tan, Ern Yu

AU - Chan, Patrick Mun Yew

AU - Muir, Kenneth

AU - Lophatananon, Artitaya

AU - Wu, Anna H.

AU - Stram, Daniel O.

AU - Matsuo, Keitaro

AU - Ito, Hidemi

AU - Chan, Ching Wan

AU - Ngeow, Joanne

AU - Yong, Wei Sean

AU - Lim, Swee Ho

AU - Lim, Geok Hoon

AU - Kwong, Ava

AU - Chan, Tsun L.

AU - Tan, Su Ming

AU - Seah, Jaime

AU - John, Esther M.

AU - Kurian, Allison W.

AU - Koh, Woon Puay

AU - Khor, Chiea Chuen

AU - Iwasaki, Motoki

AU - Yamaji, Taiki

AU - Tan, Kiak Mien Veronique

AU - Tan, Kiat Tee Benita

AU - Spinelli, John J.

AU - Aronson, Kristan J.

AU - Hasan, Siti Norhidayu

AU - Rahmat, Kartini

AU - Vijayananthan, Anushya

AU - Sim, Xueling

AU - Pharoah, Paul D.P.

AU - Zheng, Wei

AU - Dunning, Alison M.

AU - Simard, Jacques

AU - van Dam, Rob Martinus

AU - Yip, Cheng Har

AU - Taib, Nur Aishah Mohd

AU - Hartman, Mikael

AU - Easton, Douglas F.

AU - Teo, Soo Hwang

AU - Antoniou, Antonis C.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to women in the middle quintile of the risk distribution, women in the highest 1% of PRS distribution have a ~2.7-fold risk and women in the lowest 1% of PRS distribution has ~0.4-fold risk of developing breast cancer. There is no evidence of heterogeneity in PRS performance in Chinese, Malay and Indian women. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia.

AB - Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to women in the middle quintile of the risk distribution, women in the highest 1% of PRS distribution have a ~2.7-fold risk and women in the lowest 1% of PRS distribution has ~0.4-fold risk of developing breast cancer. There is no evidence of heterogeneity in PRS performance in Chinese, Malay and Indian women. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia.

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UR - http://www.scopus.com/inward/citedby.url?scp=85088859082&partnerID=8YFLogxK

U2 - 10.1038/s41467-020-17680-w

DO - 10.1038/s41467-020-17680-w

M3 - Article

C2 - 32737321

AN - SCOPUS:85088859082

SN - 2041-1723

VL - 11

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 3833

ER -

European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

Abstract

Bibliographical note

ASJC Scopus Subject Areas

UN SDGs

Access to Document

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