TY - GEN
T1 - Evaluation of the flow properties of Pollen shape hydroxyapatite particles for dry powder inhalation
AU - Hassan, Meer Saiful
AU - Wang, Yongsheng
AU - Xu, Rong
AU - Lau, Raymond
PY - 2008
Y1 - 2008
N2 - The use of pollen shape (spiked sphere) particles for dry powder inhalation is studied. Pollen shape hydroxyapatite (HA) particles are synthesized to cover both size ranges of typical drug and carrier particles for pulmonary drug delivery. The HA particles produced have geometric diameter range from 5-50 μm and effective density range from 0.2-0.72 g/cm3. The flow properties of the powders are characterized by the Carr's compressibility index (CI). The aerodynamic properties of the particles are studied in vitro by using an eight-staged Anderson Cascade Impactor with a Rotahaler®. HA samples of different sizes are used as single formulation in the experiment. The HA particles are found to have lower CI values than commonly used lactose carrier particles with similar size range. The pollen shape particles also show high emitted dose and fine particle fraction and correlates well with the corresponding mean aerodynamic diameter.
AB - The use of pollen shape (spiked sphere) particles for dry powder inhalation is studied. Pollen shape hydroxyapatite (HA) particles are synthesized to cover both size ranges of typical drug and carrier particles for pulmonary drug delivery. The HA particles produced have geometric diameter range from 5-50 μm and effective density range from 0.2-0.72 g/cm3. The flow properties of the powders are characterized by the Carr's compressibility index (CI). The aerodynamic properties of the particles are studied in vitro by using an eight-staged Anderson Cascade Impactor with a Rotahaler®. HA samples of different sizes are used as single formulation in the experiment. The HA particles are found to have lower CI values than commonly used lactose carrier particles with similar size range. The pollen shape particles also show high emitted dose and fine particle fraction and correlates well with the corresponding mean aerodynamic diameter.
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M3 - Conference contribution
AN - SCOPUS:79952301242
SN - 9780816910502
T3 - AIChE Annual Meeting, Conference Proceedings
BT - AIChE100 - 2008 AIChE Annual Meeting, Conference Proceedings
T2 - 2008 AIChE Annual Meeting, AIChE 100
Y2 - 16 November 2008 through 21 November 2008
ER -