TY - JOUR
T1 - Explaining the bias in the 23S rRNA gene mutations associated with clarithromycin resistance in clinical isolates of Helicobacter pylori
AU - Debets-Ossenkopp, Y. J.
AU - Brinkman, A. B.
AU - Kuipers, E. J.
AU - Vandenbroucke-Grauls, C. M.J.E.
AU - Kusters, J. G.
PY - 1998/10
Y1 - 1998/10
N2 - A single point mutation in the 23S rRNA gene of Helicobacter pylori is known to confer resistance to clarithromycin. Most prevalent among clarithromycin-resistant clinical H. pylori isolates are the mutations from A-2142 to G and A-2143 to G in the 23S rRNA gene. The bias in the 23S rRNA gene mutations conferring clarithromycin resistance may result from the higher MIC, stability of resistance, and growth rate found for the strains with the above-mentioned mutations.
AB - A single point mutation in the 23S rRNA gene of Helicobacter pylori is known to confer resistance to clarithromycin. Most prevalent among clarithromycin-resistant clinical H. pylori isolates are the mutations from A-2142 to G and A-2143 to G in the 23S rRNA gene. The bias in the 23S rRNA gene mutations conferring clarithromycin resistance may result from the higher MIC, stability of resistance, and growth rate found for the strains with the above-mentioned mutations.
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U2 - 10.1128/aac.42.10.2749
DO - 10.1128/aac.42.10.2749
M3 - Article
C2 - 9756790
AN - SCOPUS:0031683997
SN - 0066-4804
VL - 42
SP - 2749
EP - 2751
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 10
ER -
