Abstract
The development of catalytic synthetic approaches towards molecular complexity from simple materials continues to be an ultimate goal in synthetic chemistry. Over the past decades, N-heterocyclic carbene (NHC) organocatalysis has been extensively investigated to provide opportunities for a vast number of novel chemical transformations. Various activation modes and reactive intermediates enabled by NHC small-molecule catalysts, such as Breslow intermediates, (homo)enolates, acyl azoliums and their derived unsaturated azoliums exhibit great potential in the construction of complicated skeletons. This personal account will summarize our group's recent work in the exploration of new activation modes of NHC catalysis towards molecular complexity with a focus on the development and applications of NHC to achieve diversity and enantioselectivity in the preparation of functional molecules.
| Original language | English |
|---|---|
| Article number | e202200219 |
| Journal | Chemical Record |
| Volume | 23 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2023 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2022 The Chemical Society of Japan & Wiley-VCH GmbH.
ASJC Scopus Subject Areas
- General Chemistry
- Biochemistry
- General Chemical Engineering
- Materials Chemistry
Keywords
- Asymmetric catalysis
- Molecular complexity
- N-Heterocyclic Carbene
- NHC-bound intermediates
- Organocatalysis