Exploring new treatment for spinalized rats by synergising robotic rehabilitation system and regenerative medicine

Dolllaporn Anopas; Lin Junquan; Ulla Milbreta; Vincent Po Hen Lin; Jiah Shin Chin; Seng Kwee Wee; Tow Peh Er; Sing Yian Chew; Wei Tech Ang

doi:10.1109/EMBC.2018.8513316

Exploring new treatment for spinalized rats by synergising robotic rehabilitation system and regenerative medicine

Dolllaporn Anopas, Lin Junquan, Ulla Milbreta, Vincent Po Hen Lin, Jiah Shin Chin, Seng Kwee Wee, Tow Peh Er, Sing Yian Chew, Wei Tech Ang

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

7 Citations (Scopus)

Abstract

Spinal cord injury (SCI) is a traumatic event which leads to the loss of sensory and motor functions of the body. Complete recovery of these functions are usually limited due to the inability of the damaged axons within the central nervous system (CNS) to regenerate autonomously. Here, a combinatorial regenerative and rehabilitative approach to regrow damaged axons was proposed. Sprague-Dawley rats were subjected to a severe T9-T10 full tranection injury with a 2mm gap. Neurotrophin-3 (NT-3) loaded fibrous scaffold was implanted within the gap to provide topographical guidance for the axons to cross the injured region. To study the effect of rehabilitation, the rats were separated into 2 groups; those that undergo rehabilitation (trained, N=4) and those that do not undergo rehabilitation (untrained, N=3). In order to rehabilitate the rats, a rehabilitation robotic system consisting of a body weight support, hindlimb manipulator, and treadmill was developed. Preliminary results showed that rats which underwent rehabilitation had more robust axonal regeneration within the scaffold after 1 month. However, the Basso, Beattie, and Bresnahan (BBB) score, which is an indicator of locomotor recovery, do not show much significance between trained and untrained rats.

Original language	English
Title of host publication	40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	4205-4208
Number of pages	4
ISBN (Electronic)	9781538636466
DOIs	https://doi.org/10.1109/EMBC.2018.8513316
Publication status	Published - Oct 26 2018
Externally published	Yes
Event	40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 - Honolulu, United States Duration: Jul 18 2018 → Jul 21 2018

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume	2018-July
ISSN (Print)	1557-170X

Conference

Conference	40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
Country/Territory	United States
City	Honolulu
Period	7/18/18 → 7/21/18

Bibliographical note

Publisher Copyright:
© 2018 IEEE.

ASJC Scopus Subject Areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

Access to Document

10.1109/EMBC.2018.8513316

Cite this

Anopas, D., Junquan, L., Milbreta, U., Lin, V. P. H., Chin, J. S., Wee, S. K., Er, T. P., Chew, S. Y., & Ang, W. T. (2018). Exploring new treatment for spinalized rats by synergising robotic rehabilitation system and regenerative medicine. In 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 (pp. 4205-4208). Article 8513316 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2018-July). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2018.8513316

Anopas, Dolllaporn ; Junquan, Lin ; Milbreta, Ulla et al. / Exploring new treatment for spinalized rats by synergising robotic rehabilitation system and regenerative medicine. 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Institute of Electrical and Electronics Engineers Inc., 2018. pp. 4205-4208 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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title = "Exploring new treatment for spinalized rats by synergising robotic rehabilitation system and regenerative medicine",

abstract = "Spinal cord injury (SCI) is a traumatic event which leads to the loss of sensory and motor functions of the body. Complete recovery of these functions are usually limited due to the inability of the damaged axons within the central nervous system (CNS) to regenerate autonomously. Here, a combinatorial regenerative and rehabilitative approach to regrow damaged axons was proposed. Sprague-Dawley rats were subjected to a severe T9-T10 full tranection injury with a 2mm gap. Neurotrophin-3 (NT-3) loaded fibrous scaffold was implanted within the gap to provide topographical guidance for the axons to cross the injured region. To study the effect of rehabilitation, the rats were separated into 2 groups; those that undergo rehabilitation (trained, N=4) and those that do not undergo rehabilitation (untrained, N=3). In order to rehabilitate the rats, a rehabilitation robotic system consisting of a body weight support, hindlimb manipulator, and treadmill was developed. Preliminary results showed that rats which underwent rehabilitation had more robust axonal regeneration within the scaffold after 1 month. However, the Basso, Beattie, and Bresnahan (BBB) score, which is an indicator of locomotor recovery, do not show much significance between trained and untrained rats.",

author = "Dolllaporn Anopas and Lin Junquan and Ulla Milbreta and Lin, \{Vincent Po Hen\} and Chin, \{Jiah Shin\} and Wee, \{Seng Kwee\} and Er, \{Tow Peh\} and Chew, \{Sing Yian\} and Ang, \{Wei Tech\}",

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Anopas, D, Junquan, L, Milbreta, U, Lin, VPH, Chin, JS, Wee, SK, Er, TP, Chew, SY & Ang, WT 2018, Exploring new treatment for spinalized rats by synergising robotic rehabilitation system and regenerative medicine. in 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018., 8513316, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2018-July, Institute of Electrical and Electronics Engineers Inc., pp. 4205-4208, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018, Honolulu, United States, 7/18/18. https://doi.org/10.1109/EMBC.2018.8513316

Exploring new treatment for spinalized rats by synergising robotic rehabilitation system and regenerative medicine. / Anopas, Dolllaporn; Junquan, Lin; Milbreta, Ulla et al.
40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Institute of Electrical and Electronics Engineers Inc., 2018. p. 4205-4208 8513316 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2018-July).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Anopas, Dolllaporn

AU - Junquan, Lin

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AU - Chin, Jiah Shin

AU - Wee, Seng Kwee

AU - Er, Tow Peh

AU - Chew, Sing Yian

AU - Ang, Wei Tech

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Anopas D, Junquan L, Milbreta U, Lin VPH, Chin JS, Wee SK et al. Exploring new treatment for spinalized rats by synergising robotic rehabilitation system and regenerative medicine. In 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Institute of Electrical and Electronics Engineers Inc. 2018. p. 4205-4208. 8513316. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC.2018.8513316

Exploring new treatment for spinalized rats by synergising robotic rehabilitation system and regenerative medicine

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