Exposure to titanium dioxide nanoparticles induces autophagy in primary human keratinocytes

Yun Zhao; Josephine L.C. Howe; Zhang Yu; David Tai Leong; Justin Jang Hann Chu; Joachim Say Chye Loo; Kee Woei Ng

doi:10.1002/smll.201201363

Exposure to titanium dioxide nanoparticles induces autophagy in primary human keratinocytes

Yun Zhao, Josephine L.C. Howe, Zhang Yu, David Tai Leong, Justin Jang Hann Chu, Joachim Say Chye Loo, Kee Woei Ng^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

100 Citations (Scopus)

Abstract

Understanding the mechanisms of cell-nanomaterial interactions is vital in harnessing the potential of using nanomaterials in biomedical applications. By immuno-labeling of LC3 and TEM analysis, it is found that titanium dioxide nanoparticles are internalized by human keratinocytes and induce autophagy. Autophagy appears to play a cytoprotective role in response to toxicity influence exerted by the nanoparticles.

Original language	English
Pages (from-to)	387-392
Number of pages	6
Journal	Small
Volume	9
Issue number	3
DOIs	https://doi.org/10.1002/smll.201201363
Publication status	Published - Feb 11 2013
Externally published	Yes

ASJC Scopus Subject Areas

Biotechnology
General Chemistry
Biomaterials
General Materials Science
Engineering (miscellaneous)

Keywords

autophagy
keratinocytes
nanoparticles
nanotoxicology
titanium dioxide

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10.1002/smll.201201363

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abstract = "Understanding the mechanisms of cell-nanomaterial interactions is vital in harnessing the potential of using nanomaterials in biomedical applications. By immuno-labeling of LC3 and TEM analysis, it is found that titanium dioxide nanoparticles are internalized by human keratinocytes and induce autophagy. Autophagy appears to play a cytoprotective role in response to toxicity influence exerted by the nanoparticles.",

keywords = "autophagy, keratinocytes, nanoparticles, nanotoxicology, titanium dioxide",

author = "Yun Zhao and Howe, {Josephine L.C.} and Zhang Yu and Leong, {David Tai} and Chu, {Justin Jang Hann} and Loo, {Joachim Say Chye} and Ng, {Kee Woei}",

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AU - Zhao, Yun

AU - Howe, Josephine L.C.

AU - Yu, Zhang

AU - Leong, David Tai

AU - Chu, Justin Jang Hann

AU - Loo, Joachim Say Chye

AU - Ng, Kee Woei

PY - 2013/2/11

Y1 - 2013/2/11

N2 - Understanding the mechanisms of cell-nanomaterial interactions is vital in harnessing the potential of using nanomaterials in biomedical applications. By immuno-labeling of LC3 and TEM analysis, it is found that titanium dioxide nanoparticles are internalized by human keratinocytes and induce autophagy. Autophagy appears to play a cytoprotective role in response to toxicity influence exerted by the nanoparticles.

AB - Understanding the mechanisms of cell-nanomaterial interactions is vital in harnessing the potential of using nanomaterials in biomedical applications. By immuno-labeling of LC3 and TEM analysis, it is found that titanium dioxide nanoparticles are internalized by human keratinocytes and induce autophagy. Autophagy appears to play a cytoprotective role in response to toxicity influence exerted by the nanoparticles.

KW - autophagy

KW - keratinocytes

KW - nanoparticles

KW - nanotoxicology

KW - titanium dioxide

UR - http://www.scopus.com/inward/record.url?scp=84873359008&partnerID=8YFLogxK

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SP - 387

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JO - Small

JF - Small

IS - 3

ER -

Exposure to titanium dioxide nanoparticles induces autophagy in primary human keratinocytes

Abstract

ASJC Scopus Subject Areas

Keywords

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