Fabrication of ultrathin Zn(OH)2 nanosheets as drug carriers

Ren Cai; Dan Yang; Jin Wu; Liqin Zhang; Cuichen Wu; Xigao Chen; Yanyue Wang; Shuo Wan; Fengwei Hou; Qingyu Yan; Weihong Tan

doi:10.1007/s12274-016-1138-2

Fabrication of ultrathin Zn(OH)₂ nanosheets as drug carriers

Ren Cai, Dan Yang, Jin Wu, Liqin Zhang, Cuichen Wu, Xigao Chen, Yanyue Wang, Shuo Wan, Fengwei Hou, Qingyu Yan, Weihong Tan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Ultrathin two-dimensional (2D) porous Zn(OH)₂ nanosheets (PNs) were fabricated by means of one-dimensional Cu nanowires as backbones. The PNs have thickness of approximately 3.8 nm and pore size of 4–10 nm. To form “smart” porous nanosheets, DNA aptamers were covalently conjugated to the surface of PNs. These ultrathin nanosheets show good biocompatibility, efficient cellular uptake, and promising pH-stimulated drug release. [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	2520-2530
Number of pages	11
Journal	Nano Research
Volume	9
Issue number	8
DOIs	https://doi.org/10.1007/s12274-016-1138-2
Publication status	Published - Aug 1 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016, Tsinghua University Press and Springer-Verlag Berlin Heidelberg.

ASJC Scopus Subject Areas

Atomic and Molecular Physics, and Optics
General Materials Science
Condensed Matter Physics
Electrical and Electronic Engineering

Keywords

aptamer
cancer cell
cell-targeted delivery
porous Zn(OH) nanosheets

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s12274-016-1138-2

Cite this

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AU - Cai, Ren

AU - Yang, Dan

AU - Wu, Jin

AU - Zhang, Liqin

AU - Wu, Cuichen

AU - Chen, Xigao

AU - Wang, Yanyue

AU - Wan, Shuo

AU - Hou, Fengwei

AU - Yan, Qingyu

AU - Tan, Weihong

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