Feasibility study of pollen-shape drug carriers in dry powder inhalation

Meer Saiful Hassan; Raymond Lau

doi:10.1002/jps.21913

Feasibility study of pollen-shape drug carriers in dry powder inhalation

Meer Saiful Hassan, Raymond Lau^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The feasibility of using pollen-shape carriers in dry powder inhalation is studied. Pollen-shape hydroxyapatite (HA) particles are synthesized with a geometric diameter range from 21.1 to 48.6 mm and effective density range from 0.21 to 0.41 g/cm³. The flowability of the particles is characterized by the Carr's compressibility index (CI) and angle of slide (θ). The HA carriers are found to have better flowability than commonly used lactose (LA) carrier with similar size range. The HA carriers are also found to be capable of high drug attachment. The aerosolization and deposition properties of a model drug are compared using HA and LA as carriers. Results indicate that pollen-shape HA carriers have good potential to be used as drug carrier in dry powder inhalation. It can give higher drug emission and respirable fraction than traditional LA carriers.

Original language	English
Pages (from-to)	1309-1321
Number of pages	13
Journal	Journal of Pharmaceutical Sciences
Volume	99
Issue number	3
DOIs	https://doi.org/10.1002/jps.21913
Publication status	Published - Mar 2010
Externally published	Yes

ASJC Scopus Subject Areas

Pharmaceutical Science

Keywords

Aerosols
Dry powder inhalation
Pollen-shape carriers
Pulmonary delivery

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10.1002/jps.21913

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abstract = "The feasibility of using pollen-shape carriers in dry powder inhalation is studied. Pollen-shape hydroxyapatite (HA) particles are synthesized with a geometric diameter range from 21.1 to 48.6 mm and effective density range from 0.21 to 0.41 g/cm3. The flowability of the particles is characterized by the Carr's compressibility index (CI) and angle of slide (θ). The HA carriers are found to have better flowability than commonly used lactose (LA) carrier with similar size range. The HA carriers are also found to be capable of high drug attachment. The aerosolization and deposition properties of a model drug are compared using HA and LA as carriers. Results indicate that pollen-shape HA carriers have good potential to be used as drug carrier in dry powder inhalation. It can give higher drug emission and respirable fraction than traditional LA carriers.",

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AU - Lau, Raymond

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AB - The feasibility of using pollen-shape carriers in dry powder inhalation is studied. Pollen-shape hydroxyapatite (HA) particles are synthesized with a geometric diameter range from 21.1 to 48.6 mm and effective density range from 0.21 to 0.41 g/cm3. The flowability of the particles is characterized by the Carr's compressibility index (CI) and angle of slide (θ). The HA carriers are found to have better flowability than commonly used lactose (LA) carrier with similar size range. The HA carriers are also found to be capable of high drug attachment. The aerosolization and deposition properties of a model drug are compared using HA and LA as carriers. Results indicate that pollen-shape HA carriers have good potential to be used as drug carrier in dry powder inhalation. It can give higher drug emission and respirable fraction than traditional LA carriers.

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KW - Dry powder inhalation

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KW - Pulmonary delivery

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Feasibility study of pollen-shape drug carriers in dry powder inhalation

Abstract

ASJC Scopus Subject Areas

Keywords

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