Formal synthesis of chelamidine alkaloids and their derivatives

Rui Qi Li; Yu He; Yao Ding; Chee Kiat Ang; Jie Sheng Tian; Teck Peng Loh

doi:10.1039/c7cc09875h

Formal synthesis of chelamidine alkaloids and their derivatives

Rui Qi Li, Yu He, Yao Ding, Chee Kiat Ang, Jie Sheng Tian^*, Teck Peng Loh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A concise two-step operation of α-amination of aldehydes and subsequent Friedel-Crafts/Prins-type cyclization towards accessing tetrahydrobenzo[c]phenanthridine and related structures was developed. The reaction displayed a broad substrate scope and good tolerance to a variety of substituents such as different aromatic heterocyclic rings. In addition, the effectiveness of this protocol was also demonstrated in the formal synthesis of homochelidonine and chelamidine.

Original language	English
Pages (from-to)	3150-3153
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	25
DOIs	https://doi.org/10.1039/c7cc09875h
Publication status	Published - 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry.

ASJC Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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AU - Li, Rui Qi

AU - He, Yu

AU - Ding, Yao

AU - Ang, Chee Kiat

AU - Tian, Jie Sheng

AU - Loh, Teck Peng

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2018

Y1 - 2018

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Formal synthesis of chelamidine alkaloids and their derivatives

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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