TY - JOUR
T1 - From North Asia to South America
T2 - Tracing the longest human migration through genomic sequencing
AU - Gusareva, Elena S.
AU - Ghosh, Amit Gourav
AU - Kharkov, Vladimir N.
AU - Khor, Seik Soon
AU - Zarubin, Aleksei
AU - Moshkov, Nikita
AU - Kalsi, Namrata
AU - Ratan, Aakrosh
AU - Heinle, Cassie E.
AU - Cooke, Niall
AU - Bravi, Claudio M.
AU - Smolnikova, Marina V.
AU - Tereshchenko, Sergey Yu
AU - Kasparov, Eduard W.
AU - Khitrinskaya, Irina
AU - Marusin, Andrey
AU - Razhabov, Magomed O.
AU - Golubenko, Maria V.
AU - Swarovskaya, Maria
AU - Kolesnikov, Nikita A.
AU - Vagaitseva, Ksenia V.
AU - Eremina, Elena R.
AU - Sukhomyasova, Aitalina
AU - Shtygasheva, Olga
AU - Panicker, Deepa
AU - Ang, Poh Nee
AU - Lee, Choou Fook
AU - Koh, Yanqing
AU - Leong, See Ting
AU - Park, Changsook
AU - Lohar, Sachin R.
AU - Yap, Zhei Hwee
AU - Ng, Soo Guek
AU - Dacanay, Justine
AU - Drautz-Moses, Daniela I.
AU - Ramli, Nurul Adilah Binte
AU - Tokunaga, Katsushi
AU - McGonigle, Ian
AU - Danjoh, Inaho
AU - Moreno-Estrada, Andrés
AU - Tajima, Atsushi
AU - Tanabe, Hideyuki
AU - Nakamura, Yukio
AU - Nakagome, Shigeki
AU - Tatarinova, Tatiana V.
AU - Stepanov, Vadim A.
AU - Schuster, Stephan C.
AU - Kim, Hie Lim
PY - 2025/5/15
Y1 - 2025/5/15
N2 - Genome sequencing of 1537 individuals from 139 ethnic groups reveals the genetic characteristics of understudied populations in North Asia and South America. Our analysis demonstrates that West Siberian ancestry, represented by the Kets and Nenets, contributed to the genetic ancestry of most Siberian populations. West Beringians, including the Koryaks, Inuit, and Luoravetlans, exhibit genetic adaptation to Arctic climate, including medically relevant variants. In South America, early migrants split into four groups-Amazonians, Andeans, Chaco Amerindians, and Patagonians-~13,900 years ago. Their longest migration led to population decline, whereas settlement in South America's diverse environments caused instant spatial isolation, reducing genetic and immunogenic diversity. These findings highlight how population history and environmental pressures shaped the genetic architecture of human populations across North Asia and South America.
AB - Genome sequencing of 1537 individuals from 139 ethnic groups reveals the genetic characteristics of understudied populations in North Asia and South America. Our analysis demonstrates that West Siberian ancestry, represented by the Kets and Nenets, contributed to the genetic ancestry of most Siberian populations. West Beringians, including the Koryaks, Inuit, and Luoravetlans, exhibit genetic adaptation to Arctic climate, including medically relevant variants. In South America, early migrants split into four groups-Amazonians, Andeans, Chaco Amerindians, and Patagonians-~13,900 years ago. Their longest migration led to population decline, whereas settlement in South America's diverse environments caused instant spatial isolation, reducing genetic and immunogenic diversity. These findings highlight how population history and environmental pressures shaped the genetic architecture of human populations across North Asia and South America.
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U2 - 10.1126/science.adk5081
DO - 10.1126/science.adk5081
M3 - Article
C2 - 40373127
AN - SCOPUS:105005477424
SN - 0036-8075
VL - 388
SP - eadk5081
JO - Science
JF - Science
IS - 6748
ER -