Functionalization of peptides and proteins by Mukaiyama aldol reaction

Jenefer Alam; Thomas H. Keller; Teck Peng Loh

doi:10.1021/ja102733a

Functionalization of peptides and proteins by Mukaiyama aldol reaction

Jenefer Alam, Thomas H. Keller, Teck Peng Loh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

The scope of the catalyst-free water-based Mukaiyama aldol reaction was explored through its application to the site-selective functionalization of N-terminal aldehydes of peptides and proteins. Various functional groups were introduced under mild and environmentally friendly conditions, with the first demonstration of aldol C-C bond formation in protein labeling studies. The efficiency and speed achieved in protein labeling can be of special interest in chemical biology studies.

Original language	English
Pages (from-to)	9546-9548
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	132
Issue number	28
DOIs	https://doi.org/10.1021/ja102733a
Publication status	Published - Jul 21 2010
Externally published	Yes

ASJC Scopus Subject Areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja102733a

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Functionalization of peptides and proteins by Mukaiyama aldol reaction

Abstract

ASJC Scopus Subject Areas

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