Gadolinium oxide ultranarrow nanorods as multimodal contrast agents for optical and magnetic resonance imaging

Gautom Kumar Das; Boon Chin Heng; Sui Choon Ng; Tim White; Joachim Say Chye Loo; Loyola D'Silva; Parasuraman Padmanabhan; Kishore K. Bhakoo; Subramanian Tamil Selvan; Timothy Thatt Yang Tan

doi:10.1021/la904751q

Gadolinium oxide ultranarrow nanorods as multimodal contrast agents for optical and magnetic resonance imaging

Gautom Kumar Das, Boon Chin Heng, Sui Choon Ng, Tim White, Joachim Say Chye Loo, Loyola D'Silva, Parasuraman Padmanabhan, Kishore K. Bhakoo, Subramanian Tamil Selvan, Timothy Thatt Yang Tan

Research output: Contribution to journal › Article › peer-review

166 Citations (Scopus)

Abstract

We demonstrate a simple synthetic strategy for the fabrication of single-phase rare earth (RE) doped gadolinium oxide (Gd₂O ₃:RE where RE = terbium (Tb), ytterbium (Yb), and erbium (Er)) nanorods (NRs) as multimodal imaging probes. The NRs are ultranarrow and exhibit both emission and magnetic characteristics. The Tb-doped and Yb/Er-codoped Gd₂O₃ NRs exhibit down- and up-conversion fluorescence respectively, and also exhibit paramagnetism. Importantly, these codoped NRs possess excellent magnetic characteristics, as shown in their longitudinal relaxation time (T1) -weighted image contrast, which is closer to that of commercial Gadovist for magnetic resonance imaging (MRI) applications. This property opens up new avenues in the development of contrast agents.

Original language	English
Pages (from-to)	8959-8965
Number of pages	7
Journal	Langmuir
Volume	26
Issue number	11
DOIs	https://doi.org/10.1021/la904751q
Publication status	Published - Jun 1 2010
Externally published	Yes

ASJC Scopus Subject Areas

General Materials Science
Condensed Matter Physics
Surfaces and Interfaces
Spectroscopy
Electrochemistry

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10.1021/la904751q

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title = "Gadolinium oxide ultranarrow nanorods as multimodal contrast agents for optical and magnetic resonance imaging",

abstract = "We demonstrate a simple synthetic strategy for the fabrication of single-phase rare earth (RE) doped gadolinium oxide (Gd2O 3:RE where RE = terbium (Tb), ytterbium (Yb), and erbium (Er)) nanorods (NRs) as multimodal imaging probes. The NRs are ultranarrow and exhibit both emission and magnetic characteristics. The Tb-doped and Yb/Er-codoped Gd2O3 NRs exhibit down- and up-conversion fluorescence respectively, and also exhibit paramagnetism. Importantly, these codoped NRs possess excellent magnetic characteristics, as shown in their longitudinal relaxation time (T1) -weighted image contrast, which is closer to that of commercial Gadovist for magnetic resonance imaging (MRI) applications. This property opens up new avenues in the development of contrast agents.",

author = "Das, {Gautom Kumar} and Heng, {Boon Chin} and Ng, {Sui Choon} and Tim White and Loo, {Joachim Say Chye} and Loyola D'Silva and Parasuraman Padmanabhan and Bhakoo, {Kishore K.} and Selvan, {Subramanian Tamil} and Tan, {Timothy Thatt Yang}",

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doi = "10.1021/la904751q",

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T1 - Gadolinium oxide ultranarrow nanorods as multimodal contrast agents for optical and magnetic resonance imaging

AU - Das, Gautom Kumar

AU - Heng, Boon Chin

AU - Ng, Sui Choon

AU - White, Tim

AU - Loo, Joachim Say Chye

AU - D'Silva, Loyola

AU - Padmanabhan, Parasuraman

AU - Bhakoo, Kishore K.

AU - Selvan, Subramanian Tamil

AU - Tan, Timothy Thatt Yang

PY - 2010/6/1

Y1 - 2010/6/1

N2 - We demonstrate a simple synthetic strategy for the fabrication of single-phase rare earth (RE) doped gadolinium oxide (Gd2O 3:RE where RE = terbium (Tb), ytterbium (Yb), and erbium (Er)) nanorods (NRs) as multimodal imaging probes. The NRs are ultranarrow and exhibit both emission and magnetic characteristics. The Tb-doped and Yb/Er-codoped Gd2O3 NRs exhibit down- and up-conversion fluorescence respectively, and also exhibit paramagnetism. Importantly, these codoped NRs possess excellent magnetic characteristics, as shown in their longitudinal relaxation time (T1) -weighted image contrast, which is closer to that of commercial Gadovist for magnetic resonance imaging (MRI) applications. This property opens up new avenues in the development of contrast agents.

AB - We demonstrate a simple synthetic strategy for the fabrication of single-phase rare earth (RE) doped gadolinium oxide (Gd2O 3:RE where RE = terbium (Tb), ytterbium (Yb), and erbium (Er)) nanorods (NRs) as multimodal imaging probes. The NRs are ultranarrow and exhibit both emission and magnetic characteristics. The Tb-doped and Yb/Er-codoped Gd2O3 NRs exhibit down- and up-conversion fluorescence respectively, and also exhibit paramagnetism. Importantly, these codoped NRs possess excellent magnetic characteristics, as shown in their longitudinal relaxation time (T1) -weighted image contrast, which is closer to that of commercial Gadovist for magnetic resonance imaging (MRI) applications. This property opens up new avenues in the development of contrast agents.

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Gadolinium oxide ultranarrow nanorods as multimodal contrast agents for optical and magnetic resonance imaging

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ASJC Scopus Subject Areas

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