Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs

Wei Li Lee, Peixin Wee, Chandra Nugraha, Say Chye Joachim Loo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Floating polymeric microcapsules that simultaneously entrap multiple drugs were prepared using a solid/water/oil/water emulsion solvent evaporation method, based on harnessing interfacial phenomena and manipulation of the solvent removal process. The fabricated microcapsules exhibited excellent buoyancy in simulated gastric fluid and provided controlled and sustained release of multiple drugs for up to 24 h, thus revealing their potential as a rate-controlled oral drug delivery system.

Original languageEnglish
Pages (from-to)1090-1095
Number of pages6
JournalJournal of Materials Chemistry B
Volume1
Issue number8
DOIs
Publication statusPublished - Feb 28 2013
Externally publishedYes

ASJC Scopus Subject Areas

  • General Chemistry
  • Biomedical Engineering
  • General Materials Science

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