Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population

Dennis E.K. Tan; Jia Nee Foo; Jin Xin Bei; Jiang Chang; Roujun Peng; Xiaohui Zheng; Lixuan Wei; Ying Huang; Wei Yen Lim; Juan Li; Qian Cui; Soo Hong Chew; Richard P. Ebstein; Ponnudurai Kuperan; Soon Thye Lim; Miriam Tao; Suat Hoon Tan; Alvin Wong; Gee Chuan Wong; Soo Yong Tan; Siok Bian Ng; Yi Xin Zeng; Chiea Chuen Khor; Dongxin Lin; Adeline L.H. Seow; Wei Hua Jia; Jianjun Liu

doi:10.1038/ng.2666

Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population

Dennis E.K. Tan, Jia Nee Foo, Jin Xin Bei, Jiang Chang, Roujun Peng, Xiaohui Zheng, Lixuan Wei, Ying Huang, Wei Yen Lim, Juan Li, Qian Cui, Soo Hong Chew, Richard P. Ebstein, Ponnudurai Kuperan, Soon Thye Lim, Miriam Tao, Suat Hoon Tan, Alvin Wong, Gee Chuan Wong, Soo Yong TanSiok Bian Ng, Yi Xin Zeng, Chiea Chuen Khor, Dongxin Lin, Adeline L.H. Seow, Wei Hua Jia, Jianjun Liu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

To identify genetic risk factors underlying non-Hodgkin lymphomas (NHLs) from the B cell lineage, we conducted a genome-wide association study (GWAS) of 253 Chinese individuals with B cell NHL (cases) and 1,438 controls and further validation in 1,175 cases and 5,492 controls. We identified a new susceptibility locus, rs6773854, located between BCL6 (encoding B cell lymphoma protein 6) and LPP (encoding lipoma preferred partner) on oncogene-rich chromosome 3q27 that was significantly associated with increased risk of B cell NHL (meta-analysis P = 3.36 × 10 -13, per-allele odds ratio (OR) = 1.44) and with diffuse large B cell lymphoma (DLBCL) in particular (meta-analysis P = 1.14 × 10 -11, OR = 1.47). We found no evidence of association of rs6773854 with non-B cell NHLs (T cell and natural killer (NK) lineages) (P = 0.17, OR = 1.12) and observed significant heterogeneity between B cell and non-B cell subtypes (P het = 0.01, I 2 = 84%). Our results provide insight that germline variation in the intergenic region between BCL6 and LPP has a role in risk of B cell lymphomagenesis.

Original language	English
Pages (from-to)	804-807
Number of pages	4
Journal	Nature Genetics
Volume	45
Issue number	7
DOIs	https://doi.org/10.1038/ng.2666
Publication status	Published - Jul 2013
Externally published	Yes

ASJC Scopus Subject Areas

Genetics

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10.1038/ng.2666

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Tan, D. E. K., Foo, J. N., Bei, J. X., Chang, J., Peng, R., Zheng, X., Wei, L., Huang, Y., Lim, W. Y., Li, J., Cui, Q., Chew, S. H., Ebstein, R. P., Kuperan, P., Lim, S. T., Tao, M., Tan, S. H., Wong, A., Wong, G. C., ... Liu, J. (2013). Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population. Nature Genetics, 45(7), 804-807. https://doi.org/10.1038/ng.2666

@article{f1c9f9355a4c4a6783908772fa914e25,

title = "Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population",

abstract = "To identify genetic risk factors underlying non-Hodgkin lymphomas (NHLs) from the B cell lineage, we conducted a genome-wide association study (GWAS) of 253 Chinese individuals with B cell NHL (cases) and 1,438 controls and further validation in 1,175 cases and 5,492 controls. We identified a new susceptibility locus, rs6773854, located between BCL6 (encoding B cell lymphoma protein 6) and LPP (encoding lipoma preferred partner) on oncogene-rich chromosome 3q27 that was significantly associated with increased risk of B cell NHL (meta-analysis P = 3.36 × 10 -13, per-allele odds ratio (OR) = 1.44) and with diffuse large B cell lymphoma (DLBCL) in particular (meta-analysis P = 1.14 × 10 -11, OR = 1.47). We found no evidence of association of rs6773854 with non-B cell NHLs (T cell and natural killer (NK) lineages) (P = 0.17, OR = 1.12) and observed significant heterogeneity between B cell and non-B cell subtypes (P het = 0.01, I 2 = 84%). Our results provide insight that germline variation in the intergenic region between BCL6 and LPP has a role in risk of B cell lymphomagenesis.",

author = "Tan, {Dennis E.K.} and Foo, {Jia Nee} and Bei, {Jin Xin} and Jiang Chang and Roujun Peng and Xiaohui Zheng and Lixuan Wei and Ying Huang and Lim, {Wei Yen} and Juan Li and Qian Cui and Chew, {Soo Hong} and Ebstein, {Richard P.} and Ponnudurai Kuperan and Lim, {Soon Thye} and Miriam Tao and Tan, {Suat Hoon} and Alvin Wong and Wong, {Gee Chuan} and Tan, {Soo Yong} and Ng, {Siok Bian} and Zeng, {Yi Xin} and Khor, {Chiea Chuen} and Dongxin Lin and Seow, {Adeline L.H.} and Jia, {Wei Hua} and Jianjun Liu",

year = "2013",

month = jul,

doi = "10.1038/ng.2666",

language = "English",

volume = "45",

pages = "804--807",

journal = "Nature Genetics",

issn = "1061-4036",

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Tan, DEK, Foo, JN, Bei, JX, Chang, J, Peng, R, Zheng, X, Wei, L, Huang, Y, Lim, WY, Li, J, Cui, Q, Chew, SH, Ebstein, RP, Kuperan, P, Lim, ST, Tao, M, Tan, SH, Wong, A, Wong, GC, Tan, SY, Ng, SB, Zeng, YX, Khor, CC, Lin, D, Seow, ALH, Jia, WH & Liu, J 2013, 'Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population', Nature Genetics, vol. 45, no. 7, pp. 804-807. https://doi.org/10.1038/ng.2666

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T1 - Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population

AU - Tan, Dennis E.K.

AU - Foo, Jia Nee

AU - Bei, Jin Xin

AU - Chang, Jiang

AU - Peng, Roujun

AU - Zheng, Xiaohui

AU - Wei, Lixuan

AU - Huang, Ying

AU - Lim, Wei Yen

AU - Li, Juan

AU - Cui, Qian

AU - Chew, Soo Hong

AU - Ebstein, Richard P.

AU - Kuperan, Ponnudurai

AU - Lim, Soon Thye

AU - Tao, Miriam

AU - Tan, Suat Hoon

AU - Wong, Alvin

AU - Wong, Gee Chuan

AU - Tan, Soo Yong

AU - Ng, Siok Bian

AU - Zeng, Yi Xin

AU - Khor, Chiea Chuen

AU - Lin, Dongxin

AU - Seow, Adeline L.H.

AU - Jia, Wei Hua

AU - Liu, Jianjun

PY - 2013/7

Y1 - 2013/7

N2 - To identify genetic risk factors underlying non-Hodgkin lymphomas (NHLs) from the B cell lineage, we conducted a genome-wide association study (GWAS) of 253 Chinese individuals with B cell NHL (cases) and 1,438 controls and further validation in 1,175 cases and 5,492 controls. We identified a new susceptibility locus, rs6773854, located between BCL6 (encoding B cell lymphoma protein 6) and LPP (encoding lipoma preferred partner) on oncogene-rich chromosome 3q27 that was significantly associated with increased risk of B cell NHL (meta-analysis P = 3.36 × 10 -13, per-allele odds ratio (OR) = 1.44) and with diffuse large B cell lymphoma (DLBCL) in particular (meta-analysis P = 1.14 × 10 -11, OR = 1.47). We found no evidence of association of rs6773854 with non-B cell NHLs (T cell and natural killer (NK) lineages) (P = 0.17, OR = 1.12) and observed significant heterogeneity between B cell and non-B cell subtypes (P het = 0.01, I 2 = 84%). Our results provide insight that germline variation in the intergenic region between BCL6 and LPP has a role in risk of B cell lymphomagenesis.

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Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population

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